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Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.. Additionally we are shipping EBF1 Antibodies (50) and and many more products for this protein.
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EBF1 heterozygosity resulted in the deregulation of at least eight transcription factors involved in lymphopoiesis and the deregulation of key proteins playing crucial roles in survival, development, and differentiation of pro-B lymphocytes.
Down-regulation of EBF1 (and EBF2 (show EBF2 Proteins)) genes leads to a severe impairment of myelin formation in Schwann cells.
The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin.
the interaction of the CCR4 (show CCR4 Proteins)-NOT complex with EBF1 diversifies the function of EBF1 in a context-dependent manner and may coordinate transcriptional and post-transcriptional gene regulation.
Pax5 (show PAX5 Proteins) and Ebf1 collaborate to modulate the transcriptional response to Notch (show NOTCH1 Proteins) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.
a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 and Pax5 (show PAX5 Proteins) genes, revealing a synergistic effect of combined dose reduction of these proteins
EBF1 is an important regulator of adipose morphology and fat cell lipolysis and may constitute a link between White adipose tissue inflammation, altered lipid metabolism, adipose hypertrophy, and insulin (show INS Proteins) resistance.
Ebf1 has a significant and novel role in glomerular development, podocyte maturation, and the maintenance of kidney integrity and function.
Our results suggest that Bach2 (show BACH2 Proteins) functions with Bach1 (show BACH1 Proteins) and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells
EBF1 functions as a key integrator of signal transduction, inflammation, and metabolism
EBF1 was down-regulated in cholangiocarcinoma (CCA (show FBN2 Proteins)) tissues and cell lines.
Data show that GS Homeobox 2 (Gsx2 (show GSX2 Proteins)) and Early B-cell factor 1 (Ebf1) combined overexpression in human embryonic stem (hES (show RRBP1 Proteins)) cells achieves high yields of medium spiny neurons (MSNs).
this study demonstrates a role for the AHR (show AHR Proteins) in regulating human B cell development, and it suggests that transcriptional alterations of EBF1 by the AHR (show AHR Proteins) are involved in the underlying mechanism
In a Chinese population the TT genotype and T alleles in rs36071027 in the EBF1 gene are associated with an increased risk of coronary artery disease and its severity.
A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE (show APOE Proteins), MINIPP1, FOXO3 (show FOXO3 Proteins), EBF1, CAMKIV (show CAMK4 Proteins), and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002).
In this genomewide association study, we found that variants at the EBF1, EEFSEC (show EEFSEC Proteins), AGTR2 (show AGTR2 Proteins), WNT4 (show WNT4 Proteins), ADCY5 (show ADCY5 Proteins), and RAP2C (show RAP2C Proteins) loci were associated with gestational duration and variants at the EBF1, EEFSEC (show EEFSEC Proteins), and AGTR2 (show AGTR2 Proteins) loci with preterm birth.
EBF1 polymorphism is associated with metabolic diseases.
Among 15 childhood ALL patients with EBF1-PDGFRB (show PDGFRB Proteins) fusion proteins, the fusion arose from interstitial deletion of 5q33 (n = 11), balanced rearrangement (n = 2), or complex rearrangement (n = 2).
EBF1 is critical for transcriptional control of SLAMF1 (show SLAMF1 Proteins) gene in human B cells.
two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias
Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
early B-cell factor 1
, transcription factor COE1-like
, transcription factor COE1
, Collier, Olf and EBF transcription factor 1
, olfactory neuronal transcription factor 1
, early B-cell factor (olfactory neuronal transcription factor 1)
, olfactory neuronal transcription factor
, early B-cell factor 1 protein