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Transcriptional regulator. Additionally we are shipping EGR4 Kits (24) and EGR4 Proteins (6) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal EGR4 Primary Antibody for ELISA, WB - ABIN449533
Uvarov, Ludwig, Markkanen, Rivera, Airaksinen: Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
this study is the first to screen the EGR4 gene in relation to male infertility. However, our findings did not clearly explain how nonsynonymous EGR4 variations affect spermatogenesis
EGR4 directly transactivates specific variants (V3 and V4) of the PTHrP gene resulting in subsequent transactivation of the RANKL, IL-6 and IL-8 genes via paracrine action of the PTHrP protein.
data suggest a tendency of gender-specific association of EGR2 and EGR4 in schizophrenia.
Data found multiple differences in gene expression between the high and low infertility risk groups, confirming the importance of an intact hypothalamo-pituitary testicular axis and EGR4 in fertility development
Egr4 expression is triggered by trophic factor neurturin to upregulate K-Cl cotransporter KCC2 in immature neurons.
Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.
Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid cells, and the meiotic and elongating haploid germ cell populations.
An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (KCC2) gene expression.
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
early growth response 4
, early growth response protein 4
, early response protein NGFI-C
, nerve growth factor-induced protein C
, zinc-finger transcription factor NGFI-C (early response gene)