Echinoderm Microtubule Associated Protein Like 4 Proteins (EML4)

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). Additionally we are shipping EML4 Antibodies (41) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat EML4 EML4 313861  
EML4 27436 Q9HC35
EML4 78798 Q3UMY5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top EML4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$932.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

EML4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Echinoderm Microtubule Associated Protein Like 4 (EML4) Interaction Partners

Human Echinoderm Microtubule Associated Protein Like 4 (EML4) interaction partners

  1. a novel circRNA F-circEA-2a produced from the EML4-ALK fusion gene was identified and mainly located in the cytoplasm to promote cell migration and invasion in lung cancer cells.

  2. EML4-ALK fusion variant V3 is a high-risk feature for anaplastic lymphoma kinase-driven non-small cell lung cancer

  3. The EML4-ALK fusion gene may be a strong oncogene in younger patients with lung adenocarcinoma.

  4. lung adenocarcinoma in Asian patients aged 50 years, especially EML4-ALK and ROS1 fusion. Mutation analysis may be helpful in determining targeted therapy for the majority of these patients

  5. Mutation testing at diagnosis is feasible in the vast majority of patients with Stage IV adenocarcinoma of the lung. Patients with EGFR or EML4ALK mutation and those who received pemetrexed maintenance had better clinical outcomes.

  6. Our analysis indicated that ALK-EML4 positive non-small-cell lung cancers comprised a unique subgroup of adenocarcinomas with distinct clinicopathological characteristics. Incidence of ALK positivity was found to be higher in females and never smokers.

  7. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors

  8. identified EML4-ALK gene rearrangement in expanded circulating tumor cells from a patient with ALK-positive lung adenocarcinoma

  9. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein.

  10. The EML4-ALK-mediated upregulation of HIF1alpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4-ALK-positive NSCLC cells.

  11. We assessed the prevalence of EML4-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL), and the correlation with smoking history, thyroid transcription factor 1 (TTF1), gender and age

  12. Our findings show that group EML4-ALK variants 3a/b in non-small cell lung cancer may be a major source of ALK inhibitor resistance in the clinic.

  13. EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. VETANA and qRT-PCR are more appropriate for MPE detection. EML4-ALK rearrangement in pleural effusions has a predictive value for treatment.

  14. EML4-ALK-positive lung cancer is often highly progressive.

  15. case report in which the EML4-ALK fusion gene was identified as a second primary lung cancer after surgically resecting EGFR mutation-positive adenocarcinoma

  16. 79 (69%) were negative for echinoderm microtubule-associated protein like 4 (EML4)-ALK translocation, nine (8%) were positive and 27 (23%) were unevaluable.

  17. Data suggest that platelets are a valuable source for the non-invasive detection of echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangements and for predicting and monitoring outcome to crizotinib.

  18. Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK)-mediated stem-like properties enhances the anti-tumor effect.

  19. This review describes the biology of EML4 and ALK, explains the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK in cancer. [review]

  20. We further showed that both EML4-ALK and mutant forms of EGFR modulate PD-L1 expression via common downstream pathways mediated by MEK-ERK and by PI3K-AKT.

EML4 Protein Profile

Protein Summary

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

Gene names and symbols associated with EML4

  • echinoderm microtubule associated protein like 4 (Eml4)
  • echinoderm microtubule associated protein like 4 (EML4)
  • echinoderm microtubule associated protein like 4 (eml4)
  • echinoderm microtubule associated protein like 4 S homeolog (eml4.S)
  • 4930443C24Rik protein
  • AI644019 protein
  • C2orf2 protein
  • ELP120 protein
  • EMAP-4 protein
  • EMAPL4 protein
  • EML4 protein
  • MGC89332 protein
  • ROPP120 protein

Protein level used designations for EML4

echinoderm microtubule-associated protein-like 4 , echinoderm microtubule associated protein like 4 , echinoderm microtubule-associated protein-like 4-like , restrictedly overexpressed proliferation-associated protein , ropp 120 , EMAP-4

GENE ID SPECIES
313861 Rattus norvegicus
483048 Canis lupus familiaris
540187 Bos taurus
100515021 Sus scrofa
448764 Xenopus (Silurana) tropicalis
459180 Pan troglodytes
715091 Macaca mulatta
771345 Gallus gallus
100053784 Equus caballus
100453034 Pongo abelii
27436 Homo sapiens
78798 Mus musculus
735022 Xenopus laevis
Selected quality suppliers for EML4 Proteins (EML4)
Did you look for something else?