Ectonucleotide Pyrophosphatase/phosphodiesterase 2 Proteins (ENPP2)

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Additionally we are shipping ENPP2 Antibodies (120) and ENPP2 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ENPP2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Human Cells Cynomolgus His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HEK-293 Cells Human His tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$832.00
Details
HEK-293 Cells Human His tag   10 μg Log in to see 2 to 3 Days
$180.00
Details
HEK-293 Cells Human His tag Human ENPP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 50 μg Log in to see 2 to 3 Days
$319.00
Details
Yeast Yeast His tag   1 mg Log in to see 60 to 71 Days
$3,256.00
Details

ENPP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) , ,

Rat (Rattus)

More Proteins for Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaction Partners

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Structural and functional studies have revealed what makes ATX a unique lysoPLD, and how secreted ATX binds to its target cells. The ATX catalytic domain shows a characteristic bimetallic active site followed by a shallow binding groove that can accommodate nucleotides as well as the glycerol moiety of lysophospholipids, and by a deep lipid-binding pocket.

  2. We conclude that an ATM-ATX axis interconnects double-strand breaks with silica-induced inflammation and propagates these effects in epithelial cells

  3. we present a new crystal structure of ATX in complex with orthovanadate (ATX-VO5), which binds the Ogamma nucleophile of Thr209 and adopts a trigonal bipyramidal conformation, following the nucleophile attack onto the substrate.We propose that ATX follows the associative two-step in-line displacement mechanism.

  4. The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed.

  5. These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.

  6. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels

  7. AKT (show AKT1 Proteins) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (show NFATC3 Proteins)-mediated p23 (Sec24C (show SEC24C Proteins)) expression

  8. Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (show CYP11A1 Proteins)-6-induced ATX levels were increased i (show CYP11A1 Proteins)n fibroblasts from SSc patients compared with (show IL6 Proteins) controls.

  9. Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.

  10. These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 Proteins) and AUF1 (show HNRNPD Proteins) modulates cancer cell migration.

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. ENPP2 links Activin-A (show INHBA Proteins) enhanced mTOR (show FRAP1 Proteins) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

  2. This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.

  3. Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.

  4. These results indicate that ATX-lysophosphatidic acid-LPA3 (show LPAR3 Proteins) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (show HBEGF Proteins) and COX-2 pathways.

  5. ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (show CYP11A1 Proteins)) and enables 2 major mediators of SSc (show CYP11A1 Proteins) fibrogenesis, lysophosphatidic acid and IL-6 (show IL6 Proteins), to amplify the production of each other.

  6. These results suggest that the post-transcriptional regulation of ATX expression by HuR (show ELAVL1 Proteins) and AUF1 (show HNRNPD Proteins) modulates cancer cell migration.

  7. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  8. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  9. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  10. These findings identify ATX and LPA2 (show LPAR2 Proteins) as radiation-regulated genes that appear to play a physiological role in DNA repair.

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Zebrafish Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

  1. Autotaxin-Lysophosphatidic Acid axis acts downstream of Apoprotein (show APOE Proteins) B lipoproteins in endothelial cells.

  2. When autotaxin (Atx), was overexpressed in zebrafish embryos by injecting atx mRNA, the embryos showed cardia bifida, a phenotype induced by down-regulation of sphingosine-1-phosphate signaling.

  3. the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates

  4. This study demonstrate that the zebrafish ortholog to mammalian atx displays evolutionarily conserved expression pattern characteristics.

  5. results suggest a major role for the Atx/Lpar3 (show LPAR3 Proteins) signaling axis in regulating KV formation, ciliogenesis and L-R asymmetry via a Wnt (show WNT2 Proteins)-dependent pathway

ENPP2 Protein Profile

Protein Summary

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 L homeolog (enpp2.L)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog (enpp2.S)
  • atx protein
  • ATX-X protein
  • autotaxin protein
  • enpp2 protein
  • enpp2a protein
  • enpp2b protein
  • LysoPLD protein
  • MGC132047 protein
  • NPP2 protein
  • Npps2 protein
  • PD-Ialpha protein
  • Pdnp2 protein
  • zgc:63550 protein

Protein level used designations for ENPP2

E-NPP 2 , autotaxin-t , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , autotaxin , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog

GENE ID SPECIES
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
420361 Gallus gallus
464353 Pan troglodytes
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
100057101 Equus caballus
100332039 Danio rerio
100722506 Cavia porcellus
380218 Xenopus laevis
Selected quality suppliers for ENPP2 Proteins (ENPP2)
Did you look for something else?