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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Additionally we are shipping Elastase, Neutrophil Expressed Antibodies (176) and Elastase, Neutrophil Expressed Proteins (15) and many more products for this protein.
Showing 10 out of 106 products:
Dog (Canine) ELANE ELISA Kit for Sandwich ELISA - ABIN414213
Tang, Tao, Zhou, Zhang, Gong, Luo, Du: Long-term leukocyte filtration should be avoided during extracorporeal circulation. in Mediators of inflammation 2014
Show all 2 Pubmed References
Human ELANE ELISA Kit for Sandwich ELISA - ABIN612685
Sinha, Watorek, Karr, Giles, Bode, Travis: Primary structure of human neutrophil elastase. in Proceedings of the National Academy of Sciences of the United States of America 1987
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Mouse (Murine) ELANE ELISA Kit for Sandwich ELISA - ABIN415544
Chen, Zhou, Xiao, Huang, Zhang, Gu, Tang: Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide. in Clinical and experimental pharmacology & physiology 2017
Rat (Rattus) ELANE ELISA Kit for Sandwich ELISA - ABIN416109
Li, Jia, Ji, Gong, Wang, Zhang, Wang, Zang: The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. in International journal of molecular medicine 2016
Human ELANE ELISA Kit for Sandwich ELISA - ABIN414502
Di Cerbo, Laurino, Palmieri, Iannitti: A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. in Journal of photochemistry and photobiology. B, Biology 2015
Mouse (Murine) ELANE ELISA Kit for Sandwich ELISA - ABIN366341
Feng, Liu, Zhu, Guo, Yingchunwu, Wang, Chen, Huang, Li: Inhibition of human neutrophil elastase by pentacyclic triterpenes. in PLoS ONE 2013
Rat (Rattus) ELANE ELISA Kit for Sandwich ELISA - ABIN367994
Cao, Zhou, Chong, Fu, Zhang, Sun, Hou, Zhang, Li, Sun: Estrogen resisted stress-induced cardiomyopathy through increasing the activity of ??AR-G?s signal pathway in female rats. in International journal of cardiology 2015
Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.
Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.
The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 ELISA Kits) and CHOP (show DDIT3 ELISA Kits) is reported.
results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (show ELN ELISA Kits) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy
Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.
Data suggest that neuropilin-1 (NRP1 (show NRP1 ELISA Kits)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (show TMEM37 ELISA Kits) (a peptide fragment of NE) in breast cancer cells.
This study proposes that acquisition of CSF3R (show CSF3R ELISA Kits) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (show SRI ELISA Kits) patients.
Faecal biomarkers lactoferrin (show LTF ELISA Kits), calprotectin (show S100A8 ELISA Kits), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.
In conclusion, site-specific CBG (show SERPINA6 ELISA Kits) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (show C6orf108 ELISA Kits) proteolysis by endogenous and exogenous elastases.
Although circulating nucleosomes and elastase - alpha 1-antitrypsin (show SERPINA1 ELISA Kits) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (show SLC44A2 ELISA Kits) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.
Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (show CEBPA ELISA Kits)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (show CEBPA ELISA Kits) are resistant to HFD-induced myelopoiesis.
Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).
Serine protease (show F2 ELISA Kits) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock
Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration
results of ultrasound studies using the elastase and AngII apoE (show APOE ELISA Kits) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
SerpinA3N (show SERPINA3N ELISA Kits) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.
In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
elastase 2, neutrophil
, neutrophil elastase
, elastase, neutrophil expressed
, chymotrypsin-like elastase family member 2A
, pancreatic elastase II
, PMN elastase
, bone marrow serine protease
, granulocyte-derived elastase
, human leukocyte elastase
, leukocyte elastase
, polymorphonuclear elastase
, serine protease