Empty Spiracles Homeobox 2 Proteins (EMX2)

EMX2 encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Additionally we are shipping EMX2 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EMX2 2018 Q04743
EMX2 13797 Q04744
Rat EMX2 EMX2 499380  
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Top EMX2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

EMX2 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for Empty Spiracles Homeobox 2 (EMX2) Interaction Partners

Human Empty Spiracles Homeobox 2 (EMX2) interaction partners

  1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival.

  2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences.

  3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells.

  4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration.

  5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion.

  6. Deletions of EMX2 have been associated with a wide range of DSD.

  7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival.

  8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer

  9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo.

  10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay.

  11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma.

  12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1.

  13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes

  14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients.

  15. In these studies we identify and characterize the regulation of EMX2 by HOXA10.

  16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression.

  17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas.

  18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis.

  19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations

  20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents.

Mouse (Murine) Empty Spiracles Homeobox 2 (EMX2) interaction partners

  1. We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer.

  2. Results showed that Emx2 overexpression in cortico-cerebral stem cells inhibits astrogenesis, largely in a cell-autonomous way

  3. Emx2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo.

  4. A high incidence of urinary tract anomalies in Pax2;Emx2 were found in compound heterozygous mice that are not found in single heterozygous mice.

  5. Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation.

  6. These results strongly suggest that Emx2 is required for regulation of tight junction assembly and allowing migration of the gonadal epithelia to the mesenchyme, which are possibly mediated by suppression of Egfr expression.

  7. detailed picture of Emx2 and Foxg1 activities in cortico-cerebral histogenesis resulted from this study

  8. Emx2 expression was greatly reduced, but persisted in the telencephalon of the enhancer mutant, indicating that there exists another enhancer for Emx2 expression unique to mammalian telencephalon.

  9. Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1

  10. Emx2 and early hair cell development in the mouse inner ear are reported.

  11. activation of Emx2 by a short antisense transcript may be a prototype of a method for overexpressing single specific genes, without introducing additional copies of them into the genome

  12. Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system.

  13. Emx2 is a direct transcriptional target of Wnt and Bmp signalling and provide insights into a genetic hierarchy involving Gli3, Emx2 and Bmp and Wnt genes in the control of dorsal telencephalic development.

  14. Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double knockout mice

  15. High expression of one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to activate morphogenesis of cerebral cortex

  16. early targeting abnormality is associated with Emx2 altered expression pattern in the cortex

  17. Emx2 is essential for the terminal differentiation of granular cells and the correct formation of extrinsic and intrinsic hippocampal connections

  18. By using Northern analysis and in situ hybridization, we found that EMX2 is expressed in the adult urogenital tract in an inverse temporal pattern from HOXA10, suggestive of a negative regulatory relationship.

  19. The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development.

  20. Results indicate that EMX2 is a direct repressor of Wnt1 expression in the developing mammalian telencephalon.

EMX2 Protein Profile

Protein Summary

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Gene names and symbols associated with EMX2

  • empty spiracles homeobox 2 (EMX2)
  • empty spiracles homeobox 2 (Emx2)
  • Pdo protein
  • RGD1564797 protein

Protein level used designations for EMX2

empty spiracles homolog 2 , empty spiracles-like protein 2 , homeobox protein EMX2

2018 Homo sapiens
13797 Mus musculus
523601 Bos taurus
423923 Gallus gallus
610697 Canis lupus familiaris
499380 Rattus norvegicus
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