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ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009].. Additionally we are shipping ESRP2 Antibodies (56) and ESRP2 Kits (7) and many more products for this protein.
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Results showed that the expression patterns of these genes were indicative of the onset of EMT (show ITK Proteins) in in-vitro models, but not in tissue samples. However, the ratio between ESRP1 (show ESRP1 Proteins) or ESRP2 and RBFOX2 (show RBM9 Proteins) significantly decreased during EMT (show ITK Proteins) and positively correlated with the EMT (show ITK Proteins)-specific phenotype in cell models. Low ESRP1 (show ESRP1 Proteins)/RBFOX2 (show RBM9 Proteins) ratio value was associated with a higher risk of metastasis in early breast cancer patients.
Results indicate a tumor-suppressive role of the ring finger protein 111 (Arkadia (show RNF111 Proteins))-epithelial splicing regulatory protein 2 (ESRP2) axis in clear-cell renal cell carcinoma (show MOK Proteins) (ccRCC).
The molecular mechanisms by which ESRP1 (show ESRP1 Proteins) and ESPR2 exert positive as well as negative effects on cancer progression have been summarized. (Review)
Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes.
ESRP1 (show ESRP1 Proteins) and ESRP2 suppress cancer cell motility via different mechanisms.
functions of the ESRP2 in an epithelial posttranscriptional gene expression program.
ESRP2 coordinates a complex alternative splicing network that adds an important post-transcriptional layer to the changes in gene expression that underlie epithelial-mesenchymal transitions during development and disease.
results further establish ESRP1 (show ESRP1 Proteins) and ESRP2 as global regulators of an epithelial splicing regulatory network.
ESRP1 and ESRP2 are epithelial cell-type-specific (show ESRP1 Proteins)regulators of FGFR2 splicing.
Data show that the hypomethylated lncRNAs, 1810019D21Rik (called Esrp2-antisense (as)) was identified in proximity to the epithelial splicing regulatory protein 2 (Esrp2) that is significantly elevated in C3(1 (show C3 Proteins)) tumors.
Loss of both Esrp1 (show ESRP1 Proteins) and its paralog Esrp2 results in widespread developmental defects with broad implications to human disease.
deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) and the progression of breast cancers
Epithelial splicing regulatory proteins 1/2 (ESRP1 (show ESRP1 Proteins)/2) are epithelial cell-type-specific regulators of FGFR2 (show FGFR2 Proteins) splicing.
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009
epithelial splicing regulatory protein 2
, RNA binding motif protein 35A
, RNA binding motif protein 35B
, RNA-binding motif protein 35B
, RNA-binding protein 35B
, RNA binding motif protein 35b