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EPHX2 encodes a member of the epoxide hydrolase family. Additionally we are shipping Epoxide Hydrolase 2, Cytoplasmic Proteins (7) and Epoxide Hydrolase 2, Cytoplasmic Kits (2) and many more products for this protein.
Showing 10 out of 99 products:
Human Polyclonal EPHX2 Primary Antibody for ELISA, WB - ABIN4308763
Nelson, Subrahmanyan, Summers, Xiao, Alkayed: Soluble epoxide hydrolase dimerization is required for hydrolase activity. in The Journal of biological chemistry 2013
the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of diabetic nephropathy in the Chinese type 2 diabetes population, which could be modulated by homocysteine level status.
Single nucleotide polymorphism of EPHX2 rs751141 is associated with Early Neurological Deterioration.
The activity of Ephx2 prom (show ESR1 Antibodies)oter-coding luciferase was significantly attenuated in HEK293T cells treated with 17beta-E2.
hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of pre-eclampsia.
Study demonstrated an isolated gene change, sEH R287Q, in a core family of familial hypercholesterolemia (FH). The results showed that sEH R287Q decreased the expression level and hydrolase activity of sEH, decreased the binding of LDL to LDLR (show LDLR Antibodies) and LDL internalization in cultured hepatocyte cell line BEL (show LHX2 Antibodies)-7402.
Soluble epoxide hydrolase plays role in the choroidal neovascularization
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B (show PTK2B Antibodies)) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors.
Results showed that among type 2 diabetic patients, the combined effect of MTHFR (show MTHFR Antibodies) TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group.
we describe the bacterial expression of the recombinant N-terminal domain of sEH-P and the development of a high-throughput screening protocol using a sensitive and commercially available substrate fluorescein diphosphate. The usability of the assay system was demonstrated and novel inhibitors of sEH-P were identified.
The WT sEH formed a very tight dimer, with a KD/M in the low picomolar range. Only R287Q resulted in a large change of the KD/M However, human tissue concentrations of sEH suggest that it is always in its dimer form independently of the SNP.
Estrogen/estrogen receptor (show ESR1 Antibodies)-dependent methylation of the promoter region silences Ephx2 expression.
Data (including data from studies in knockout mice) suggest that expression of Ephx2 measured as mRNA, protein, and enzymatic activity is markedly up-regulated in corneal epithelium and retina in type 1 and type 2 diabetes; induction of Ephx2 may play roles in diabetic cataracts, diabetic retinopathy, and delayed wound healing.
These findings establish sEH in podocytes as a significant contributor to renal function under hyperglycemia. These data suggest that sEH is a potential therapeutic target for podocytopathies
Findings identify soluble epoxide hydrolase (sEH) in podocytes as a contributor to signaling events in acute renal injury and suggest that sEH inhibition may be of therapeutic value in proteinuria.
These data demonstrate that genetic deletion of sEH resulted in an altered oxylipin profile, which may have led to an enhanced CRH (show CRH Antibodies) response.
Deficiency or pharmacological inhibition of sEH protected mice from the lipopolysaccharide-induced decrease in systemic arterial oxygen concentration.
Lungs of Ephx2(-/-) mice had a less pronounced inflammatory response and less autophagy with mild distal airspace enlargement accompanied by restored lung function and steady weight gain
over-expression of sEH enhances A1AR (show ADORA1 Antibodies)-dependent contraction and reduces KATP channel-dependent relaxation in MAs (show MAS1 Antibodies). These results suggest a possible interaction between sEH, A1AR (show ADORA1 Antibodies), and KATP channels in regulating vascular tone.
we identified 31 significantly expressed proteins in mouse hippocampus using proteomics analysis and constructed a protein-protein interaction network associated with EPHX2 gene knockout
The role of soluble epoxide hydrolase in the pathophysiology of depression and resilience to repeated social defeat stress
AP-1 (show JUN Antibodies) activation is involved in the transcriptional up-regulation of sEH by angiotensin II (Ang II) in endothelial cells, which may contribute to Ang II (show AGT Antibodies)-induced hypertension[soluble epoxide hydrolase ]
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.
epoxide hydrolase 2
, soluble epoxide hydrolase
, Soluble epoxide hydrolase
, bifunctional epoxide hydrolase 2
, epoxide hydratase
, epoxide hydrolase 2, cytosolic
, epoxide hydrolase, soluble
, cytosolic epoxide hydrolase
, epoxide hydrolase 2C