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EBI3 was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. Additionally we are shipping EBI3 Proteins (28) and EBI3 Kits (20) and many more products for this protein.
Showing 10 out of 142 products:
Human Polyclonal EBI3 Primary Antibody for WB - ABIN1881277
Kempe, Heinz, Kokai, Devergne, Marx, Wirth: Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. in The American journal of pathology 2009
Show all 5 Pubmed References
Human Monoclonal EBI3 Primary Antibody for FACS - ABIN4896337
Long, Zhang, Wen, Kong, Lv, An, Wei: IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells. in Biochemical and biophysical research communications 2013
Human Polyclonal EBI3 Primary Antibody for ELISA - ABIN449841
Collison, Workman, Kuo, Boyd, Wang, Vignali, Cross, Sehy, Blumberg, Vignali: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. in Nature 2007
IL-35 is a relatively newly discovered member of the IL-12 (show IL12A Antibodies) family which are unique in structure as they are dimer formed by two subunits; recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases and functional analysis suggested that IL-35 is critical in the onset and development of these diseases. [Review]
Pancreatic ductal carcinoma cells produce IL35 to recruit monocytes via CCL5 (show CCL5 Antibodies) and induce macrophage to promote angiogenesis via expression of CXCL1 (show CXCL1 Antibodies) and CXCL8 (show IL8 Antibodies).
The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.
over-expression of EBI3 could reduce the apoptosis of Treg/CD4 (show CD4 Antibodies)(+)T/CD8 (show CD8A Antibodies)(+)T cells and prevent radiation-induced immunosuppression of cervical cancer HeLa cells by inhibiting the activation of PD-1 (show PDCD1 Antibodies)/PD-L1 (show CD274 Antibodies) signaling pathway
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) levels were significantly elevated in the patients with influenza infection.
IL-35 was elevated in bone marrow of adult AML (show RUNX1 Antibodies) patients and this increase was correlated with the clinical stages of malignancy, suggesting that IL-35 is involved in pathogenesis of AML (show RUNX1 Antibodies).
Data suggest that the toll like receptor 3 (TLR3 (show TLR3 Antibodies))-interferon regulatory factor 6 (show IRF6 Antibodies) protein (IRF6 (show IRF6 Antibodies))-interleukin-23 subunit p19 (p19 (show IL23A Antibodies))/EBI3 protein axis may regulate keratinocyte functions in the skin.
EBI3 gene rs4740 polymorphism is closely associated wit (show SLC11A1 Antibodies)h susceptibility to pulmonary tuberculosis and the elevation and enrichment of EBI3 in the lung derived from macrophages may contribute to the exacerbation of mycobacterial infection.
EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.
IL-35 can effectively suppress the proliferation and IL-4 (show IL4 Antibodies) production of activated CD4 (show CD4 Antibodies)+CD25 (show IL2RA Antibodies)- T cells in allergic asthma, and that IL-35 may be a new immunotherapy for asthma patients.
Data indicate an increase in the intracellular Epstein-Barr virus-induced 3 (EBI3) protein level in splenic NK cells during mouse cytomegalovirus (MCMV) infection.
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (show CD4 Antibodies)(+) CD25 (show IL2RA Antibodies)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (show TH1L Antibodies), Th2 and Th17 cells and may reduce the development of allograft rejection.
we describe here a new IL-12 member IL-39 (IL-23p19/Ebi3) secreted by activated B cells that mediate inflammatory responses in lupus-like mice. Thus, IL-39 might contribute to immunopathogenic mechanisms of SLE.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor (show VEGF Antibodies) and its receptors
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
our results demonstrate that EBI3 is an essential general regulator of inflammatory immune responses in experimental Chagas disease
Report higher EBI3 expression in the lung tissue of BCG (show SLC11A1 Antibodies)-infected mice.
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.
EBV-induced gene 3 protein
, Epstein-Barr virus induced gene 3
, IL-27 subunit beta
, IL27 subunit
, IL35 subunit
, cytokine receptor
, epstein-Barr virus-induced gene 3 protein
, interleukin-27 subunit beta
, Epstein-Barr virus induced 3
, interleukin 27 receptor beta
, epstein-Barr virus-induced gene 3 protein homolog
, Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor)