anti-Epstein-Barr Virus Induced 3 (EBI3) Antibodies

EBI3 was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. Additionally we are shipping EBI3 Proteins (38) and EBI3 Kits (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EBI3 10148 Q14213
EBI3 50498 O35228
EBI3 680609  
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Top anti-EBI3 Antibodies at antibodies-online.com

Showing 10 out of 143 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  EBI3  Sample Tissue:  Human U937 Whole Cell  Antibody Dilution:  1ug/ml WB Suggested Anti-EBI3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: U937 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged EBI3 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of IL-27B expression in HeLa (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB Figure. DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue. 100 μg Log in to see 13 to 16 Days
$259.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of EBI3 using COLO205 whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse APC FACS Detection of IL-27/IL-35 EBI3 Subunit in KG-1 Human Cell Line by Flow Cytometry. KG-1 human acute myelogenous leukemia cell line was stained with Mouse Anti-Human IL-27/IL-35 EBI3 Subunit APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$406.80
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-EBI3 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960146 dilution 1:100. Anti-EBI3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of EBI3 Antibody (C-term) Pab (ABIN1881277) pre-incubated without(lane 1) and with(lane 2) blocking peptide in 293 cell line lysate. EBI3 Antibody (C-term) (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-EBI3 Antibodies

  1. Human Polyclonal EBI3 Primary Antibody for WB - ABIN1881277 : Kempe, Heinz, Kokai, Devergne, Marx, Wirth: Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. in The American journal of pathology 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal EBI3 Primary Antibody for FACS - ABIN4896337 : Long, Zhang, Wen, Kong, Lv, An, Wei: IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells. in Biochemical and biophysical research communications 2013 (PubMed)

More Antibodies against EBI3 Interaction Partners

Human Epstein-Barr Virus Induced 3 (EBI3) interaction partners

  1. IL-35 may be involved in the inflammatory process of sarcoidosis and play an important role in the pathogenesis of the disease.

  2. Tumor associated macrophages secrete interleukin-35 (IL-35) to facilitate metastatic colonization through activation of JAK2-STAT6-GATA3 signaling to reverse epithelial-mesenchymal transition (EMT) in cancer cells.

  3. Letter: circulating IL-35 is significantly higher than healthy controls and associate with disease activity in systemic lupus erythematosus.

  4. A decrease in the IL-35 (IL-12A+EBI3) serum levels may play an important role in the pathogenesis of primary Sjogren's syndrome.

  5. IL-35 is induced during atherosclerosis development and inhibits mitochondrial reactive oxygen species-H3K14 acetylation-AP-1-mediated endothelial activation.

  6. The IL-35 levels in CagA(+) H. pylori-infected participants from peptic ulcer and H. pylori-infected asymptomatic groups were lower than individuals infected with CagA(-) strains.

  7. IL-35 may be involved in the pathogenesis of Primary biliary cirrhosis.

  8. IL-35 is a relatively newly discovered member of the IL-12 family which are unique in structure as they are dimer formed by two subunits; recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases and functional analysis suggested that IL-35 is critical in the onset and development of these diseases. [Review]

  9. IL-35 expression was significantly increased in patients with chronic hepatitis C and was positively correlated with the levels of viral RNA

  10. Pancreatic ductal carcinoma cells produce IL35 to recruit monocytes via CCL5 and induce macrophage to promote angiogenesis via expression of CXCL1 and CXCL8.

  11. The study revealed that post-therapeutic recovery of circulating IL-35 concentration might be an independent predictor for effective response to IST in pediatric AA.

  12. The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.

  13. this study introduces IL-35 as a new treatment for pemphigus

  14. over-expression of EBI3 could reduce the apoptosis of Treg/CD4(+)T/CD8(+)T cells and prevent radiation-induced immunosuppression of cervical cancer HeLa cells by inhibiting the activation of PD-1/PD-L1 signaling pathway

  15. Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) levels were significantly elevated in the patients with influenza infection.

  16. higher decidual mRNA expression in preeclampsia

  17. IL-35 was elevated in bone marrow of adult AML patients and this increase was correlated with the clinical stages of malignancy, suggesting that IL-35 is involved in pathogenesis of AML.

  18. Elevated circulating IL-35, particularly at early phase, its decrease after treatment initiation, and a positive association between synovial fluid IL-35 and disease activity support an involvement of IL-35 in the pathogenesis of RA.

  19. Data suggest that the toll like receptor 3 (TLR3)-interferon regulatory factor 6 protein (IRF6)-interleukin-23 subunit p19 (p19)/EBI3 protein axis may regulate keratinocyte functions in the skin.

  20. EBI3 gene rs4740 polymorphism is closely associated with susceptibility to pulmonary tuberculosis and the elevation and enrichment of EBI3 in the lung derived from macrophages may contribute to the exacerbation of mycobacterial infection.

Mouse (Murine) Epstein-Barr Virus Induced 3 (EBI3) interaction partners

  1. Interleukin-35 inhibited non-small cell lung cancer formation in the mice model and sensitized the cancer cells to chemotherapy drugs.

  2. Tumor associated macrophages secrete interleukin-35 (IL-35) to facilitate metastatic colonization through activation of JAK2-STAT6-GATA3 signaling to reverse epithelial-mesenchymal transition (EMT) in cancer cells.

  3. IL-35 is induced during atherosclerosis development and inhibits mitochondrial reactive oxygen species-H3K14 acetylation-AP-1-mediated endothelial activation.

  4. Data indicate an increase in the intracellular Epstein-Barr virus-induced 3 (EBI3) protein level in splenic NK cells during mouse cytomegalovirus (MCMV) infection.

  5. IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4(+) CD25(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1, Th2 and Th17 cells and may reduce the development of allograft rejection.

  6. we describe here a new IL-12 member IL-39 (IL-23p19/Ebi3) secreted by activated B cells that mediate inflammatory responses in lupus-like mice. Thus, IL-39 might contribute to immunopathogenic mechanisms of SLE.

  7. EBI3 can mediate IL-6 trans-signaling in a process that involves gp130

  8. our results suggest that IL-39 induces differentiation and/or expansion of neutrophils in lupus-prone mice.

  9. Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.

  10. IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors

  11. Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.

  12. our results demonstrate that EBI3 is an essential general regulator of inflammatory immune responses in experimental Chagas disease

  13. Report higher EBI3 expression in the lung tissue of BCG-infected mice.

  14. EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.

  15. IL-35 subunits (p35 and EBI3) have the immunoregulatory role in systemic lupus erythematosus.

  16. Lack of EBI3, p35, and IL-12 receptor beta2 caused enhanced infiltration of lymphocytes into the testicular interstitium, with increased interferon-gamma expression in the testes and autoantibody production against mainly acrosomal regions of spermatids.

  17. Data (including data from knockout mice) suggest Ebi3 (Epstein-Barr virus induced protein 3) and IL12 (interleukin 12) down-regulate helper-inducer T-lymphocyte (Th17 cell) function in immune response to Listeria monocytogenes.

  18. results indicate that EBI3 may be important in EAU initiation by Th1 cell responses and may suppress experimental autoimmune uveitis by inhibition of both Th1 and Th17 cell responses in the late/maintenance phase.

  19. Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs.

  20. the findings from the past decade identify IL-27 as a critical immunoregulatory cytokine, especially for T cells, whereas some controversy is fueled by results challenging the view of IL-27 as a classical silencer of inflammation.

EBI3 Antigen Profile

Protein Summary

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.

Gene names and symbols associated with EBI3

  • Epstein-Barr virus induced 3 (EBI3) antibody
  • Epstein-Barr virus induced 3 (ebi3) antibody
  • Epstein-Barr virus induced gene 3 (Ebi3) antibody
  • Epstein-Barr virus induced 3 (Ebi3) antibody
  • EBI-3 antibody
  • EBI3 antibody
  • IL-27 antibody
  • IL-27B antibody
  • il-27rb antibody
  • IL27B antibody
  • si:dkey-97a13.4 antibody

Protein level used designations for EBI3

EBV-induced gene 3 protein , Epstein-Barr virus induced gene 3 , IL-27 subunit beta , IL27 subunit , IL35 subunit , cytokine receptor , epstein-Barr virus-induced gene 3 protein , interleukin-27 subunit beta , Epstein-Barr virus induced 3 , Il27rbeta , interleukin 27 receptor beta , IL-27B , epstein-Barr virus-induced gene 3 protein homolog , Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor)

GENE ID SPECIES
10148 Homo sapiens
485043 Canis lupus familiaris
514933 Bos taurus
737135 Pan troglodytes
100134974 Danio rerio
50498 Mus musculus
680609 Rattus norvegicus
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