anti-Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) Antibodies

The protein encoded by EHMT1 is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. Additionally we are shipping EHMT1 Kits (4) and EHMT1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EHMT1 79813 Q9H9B1
EHMT1 362078  
EHMT1 77683 Q5DW34
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Top anti-EHMT1 Antibodies at antibodies-online.com

Showing 10 out of 134 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody (C-term) (ABIN387855). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody (Center)(ABIN387856). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody (N-term) (ABIN387854). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μL Log in to see 2 to 3 Days
$185.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of EUHMTASE (arrow) using rabbit polyclonal EHMT1 (EUHMTASE1) Antibody (N-term) (ABIN387925). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EUHMTASE gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of EUHMTASE (arrow) using rabbit polyclonal EHMT1 (EUHMTASE1) Antibody (Center) (ABIN387926). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EUHMTASE gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to EHMT1 on HeLa cell (antibody concentration 10 µg/mL). EHMT1 monoclonal antibody (M05), clone 3G1 Western Blot analysis of EHMT1 expression in Hela NE. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, ELISA, WB EHMT1 monoclonal antibody (M05), clone 3G1 Western Blot analysis of EHMT1 expression in Hela S3 NE . Immunofluorescence of monoclonal antibody to EHMT1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details

More Antibodies against EHMT1 Interaction Partners

Human Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) interaction partners

  1. our biochemical characterization clearly demonstrates that the previously reported two missense mutations of EHMT1 deteriorate HMT (show HNMT Antibodies) activity and GLP (show RCBTB1 Antibodies) function, which presumably cause KS.

  2. Neurodevelopmental disorders may be related to deficits in activity-dependent wiring of brain circuits during development. Although Kleefstra syndrome has been associated with dendritic and synaptic defects in mice and Drosophila, little is known about the role of EHMT1 in the development of cortical neuronal networks. We investigated the impact of EHMT1 deficiency at the network and single cell level.

  3. These results suggest that EHMT2 (show EHMT2 Antibodies) downregulation in CD4 (show CD4 Antibodies)(+) T-cells may be linked to a protection mechanism against the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM (show ATF7IP Antibodies)/TSP (show THBS1 Antibodies)).

  4. Regulated methylation and phosphorylation serve as a switch controlling G9a (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies) coactivator function, suggesting that this mechanism may be a general paradigm for directing specific transcription factor and coregulator actions on different genes.

  5. trr (show TXNRD1 Antibodies) and G9a (show EHMT2 Antibodies) also have common direct targets, including the Drosophila ortholog of Arc (show NOL3 Antibodies) (Arc1 (show CDH1 Antibodies)), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.

  6. missense variants in EHMT1 that lead to protein misfolding and disrupted histone mark binding can lead to Kleefstra Syndrome [case reports]

  7. we find an estrogen receptor (show ESR1 Antibodies)-independent synthetic lethal interaction between a GATA3 (show GATA3 Antibodies) frameshift mutant with an extended C-terminus and the histone methyltransferases G9A (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies), indicating perturbed epigenetic regulation

  8. Selective degradation of the mutant EHMT1 mRNA leads to Kleefstra syndrome.

  9. G9a (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies) are required for stable maintenance of imprinted DNA methylation (show HELLS Antibodies) in embryonic stem cells.

  10. the clinical picture we found in Norwegian patients with Kleefstra syndrome is similar to the findings described in the literature. An interesting point is that in the literature >85% of the patients have a deletion of 9q34.3 and the remaining have a mutation in the EHMT1 gene, whereas in this study we found 50% with a deletion, and 50% with a mutation.

Mouse (Murine) Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) interaction partners

  1. EHMT1 deficiency impaired neural network activity during the transition from uncorrelated background action potential firing to synchronized network bursting. Spontaneous bursting and excitatory synaptic currents were transiently reduced, whereas miniature excitatory postsynaptic currents were not affected.

  2. GLP (show GOLGA6A Antibodies)/G9a (show EHMT2 Antibodies) H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a (show KDM3A Antibodies)-mediated H3K9 demethylation at the Sry (show SRY Antibodies) locus in gonadal somatic cells

  3. miR (show MLXIP Antibodies)-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy

  4. EHMT1 Mediates Homeostatic Synaptic Scaling

  5. The stress-induced Brg1 (show SMARCA4 Antibodies)-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  6. data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (show EHMT2 Antibodies) are epigenetic regulators involved in gamma-globin repression and represent a novel therapeutic target for SCD (show SCD Antibodies).

  7. histone methyltransferase activities of GLP (show GOLGA6A Antibodies) and G9a (show EHMT2 Antibodies) are stimulated by neighboring nucleosomes that are premethylated at H3K9

  8. Prdm16 (show PRDM16 Antibodies) was required in young mice to suppress the expression of white-fat-selective genes in BAT (show BAAT Antibodies) through recruitment of the histone methyltransferase Ehmt1.

  9. G9a (show EHMT2 Antibodies) and GLP (show GOLGA6A Antibodies) have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion.

  10. Reduced Euchromatin histone methyltransferase 1 (show DNMT1 Antibodies) causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.

EHMT1 Antigen Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EHMT1

  • euchromatic histone lysine methyltransferase 1 (EHMT1) antibody
  • euchromatic histone lysine methyltransferase 1 (Ehmt1) antibody
  • histone-lysine N-methyltransferase EHMT2 (LOC100121084) antibody
  • euchromatic histone-lysine N-methyltransferase 1 (ehmt1) antibody
  • euchromatic histone lysine methyltransferase 1 (ehmt1) antibody
  • euchromatic histone methyltransferase 1 (Ehmt1) antibody
  • euchromatic histone-lysine N-methyltransferase 1a (ehmt1a) antibody
  • 9230102N17Rik antibody
  • bA188C12.1 antibody
  • bZ1O1.6 antibody
  • D330003E03 antibody
  • EHMT1 antibody
  • Eu-HMTase1 antibody
  • EUHMTASE1 antibody
  • FP13812 antibody
  • G9a antibody
  • GLP antibody
  • GLP1 antibody
  • KMT1D antibody
  • mKIAA1876 antibody
  • si:rp71-1o1.6 antibody
  • zgc:136244 antibody

Protein level used designations for EHMT1

G9a like protein , G9a-like protein 1 , H3-K9-HMTase 5 , histone H3-K9 methyltransferase 5 , histone-lysine N-methyltransferase EHMT1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 5 , lysine N-methyltransferase 1D , euchromatic histone methyltransferase 1 , euchromatic histone-lysine N-methyltransferase 1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 5-like , euchromatic histone methyltransferase 1a , histone methyltransferase 1

GENE ID SPECIES
79813 Homo sapiens
362078 Rattus norvegicus
417250 Gallus gallus
464891 Pan troglodytes
491224 Canis lupus familiaris
528606 Bos taurus
100023838 Monodelphis domestica
100058869 Equus caballus
100078328 Ornithorhynchus anatinus
100121084 Nasonia vitripennis
100124713 Xenopus (Silurana) tropicalis
100217666 Taeniopygia guttata
100466861 Ailuropoda melanoleuca
100538392 Meleagris gallopavo
100565730 Anolis carolinensis
77683 Mus musculus
100005761 Danio rerio
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