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ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A2 Antibodies (101) and EIF4A2 Proteins (11) and many more products for this protein.
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eIF4A2 is recruited to stress granules, suggesting sumoylation of eIF4A2 correlates with its recruitment to stress granules.
Studies indicate a developing focus on targeting eukaryotic initiation factor 4A eIF4A1 and eIF4A2 as cancer therapy.
expression is an independent prognostic factor for patients with non-small-cell lung cancer for both overall survival and disease-free survival
These data support a linear model for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, followed by mRNA destabilization.
The results indicated that eIF4AI and eIF4AII expression are linked and that the two protein isoforms exhibit functional differences.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.
interacted with NS5B protein, and the two proteins were shown to be partially colocalized in the perinuclear region
Single nucleotide polymorphisms in two relevant candidate genes for glucose homeostasis, kininogen (KNG1), and eukaryotic translation initiation factor 4alpha2 (EIF4A2) linked to type 2 diabetes.
subcellular distribution of eIF4F components may potentiate the complex assembly
A feedforward loop involving c-Myc and eIF4F that serves to link transcription and translation and that could contribute to the effects of c-Myc on cell proliferation and neoplastic growth.
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
complete sequence of the porcine EIF4A2 gene, its predicted amino acid sequence, genomic structure, expression patterns, and single nucleotide polymorphisms
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
ATP-dependent RNA helicase eIF4A-2
, eukaryotic initiation factor 4A-II
, eukaryotic translation initiation factor 4A
, protein synthesis initiation factor 4AII
, eukaryotic translation initiation factor 4A2
, eukaryotic translation initiation factor 4A, isoform 2
, translational eukaryotic inititation factor 4AII