Eukaryotic Translation Initiation Factor 4A2 Proteins (EIF4A2)

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A2 Antibodies (108) and EIF4A2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat EIF4A2 EIF4A2 303831 Q5RKI1
EIF4A2 1974 Q14240
EIF4A2 13682 P10630
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Top EIF4A2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$3,129.50
Details
Yeast Chicken His tag   1 mg 60 to 71 Days
$3,129.50
Details
Yeast Orang-Utan His tag   1 mg 60 to 71 Days
$3,129.50
Details
Yeast Cynomolgus His tag   1 mg 60 to 71 Days
$3,131.33
Details
Escherichia coli (E. coli) Human GST tag 1 mg 11 to 14 Days
$1,842.50
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg 11 to 18 Days
$596.97
Details

EIF4A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Interaction Partners

Human Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) interaction partners

  1. EIF4A2 was confirmed as a potential target of miR-5195-3p. MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer (TNBC) to paclitaxel (PTX) by downregulating EIF4A2.

  2. Eukaryotic translation initiation factor 4A2 (eIF4A2) is necessary for efficient HIV-1 replication in human lymphoid cell line. eIF4A2 depletion reduces the efficiency of viral cDNA synthesis with virion entry into target cells being unaffected. Depletion of eIF4A2 also inhibits HIV-1 spreading infection in a knockdown level-dependent manner.

  3. eIF4A2 is recruited to stress granules, suggesting sumoylation of eIF4A2 correlates with its recruitment to stress granules.

  4. Studies indicate a developing focus on targeting eukaryotic initiation factor 4A eIF4A1 and eIF4A2 as cancer therapy.

  5. expression is an independent prognostic factor for patients with non-small-cell lung cancer for both overall survival and disease-free survival

  6. These data support a linear model for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, followed by mRNA destabilization.

  7. The results indicated that eIF4AI and eIF4AII expression are linked and that the two protein isoforms exhibit functional differences.

  8. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  9. Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.

  10. interacted with NS5B protein, and the two proteins were shown to be partially colocalized in the perinuclear region

  11. Single nucleotide polymorphisms in two relevant candidate genes for glucose homeostasis, kininogen (KNG1), and eukaryotic translation initiation factor 4alpha2 (EIF4A2) linked to type 2 diabetes.

  12. subcellular distribution of eIF4F components may potentiate the complex assembly

  13. A feedforward loop involving c-Myc and eIF4F that serves to link transcription and translation and that could contribute to the effects of c-Myc on cell proliferation and neoplastic growth.

  14. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) interaction partners

  1. complete sequence of the porcine EIF4A2 gene, its predicted amino acid sequence, genomic structure, expression patterns, and single nucleotide polymorphisms

EIF4A2 Protein Profile

Protein Summary

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Gene names and symbols associated with EIF4A2

  • eukaryotic translation initiation factor 4A2 (Eif4a2)
  • eukaryotic translation initiation factor 4A2 (EIF4A2)
  • eukaryotic translation initiation factor 4A2 L homeolog (eif4a2.L)
  • eukaryotic translation initiation factor 4A2 (eif4a2)
  • microRNA 1248 (MIR1248)
  • eukaryotic translation initiation factor 4A, isoform 2 (eif4a2)
  • 4833432N07Rik protein
  • BM-010 protein
  • ddx2b protein
  • eIF-4A-II protein
  • Eif4 protein
  • EIF4A protein
  • eIF4A-II protein
  • EIF4A2 protein
  • EIF4AII protein
  • eif4f protein
  • wu:fd50g11 protein
  • xeif4aii protein
  • zgc:63783 protein

Protein level used designations for EIF4A2

ATP-dependent RNA helicase eIF4A-2 , eIF-4A-II , eIF4A-II , eukaryotic initiation factor 4A-II , eukaryotic translation initiation factor 4A , protein synthesis initiation factor 4AII , eukaryotic translation initiation factor 4A2 , eukaryotic translation initiation factor 4A, isoform 2 , translational eukaryotic inititation factor 4AII

GENE ID SPECIES
303831 Rattus norvegicus
1974 Homo sapiens
13682 Mus musculus
379831 Xenopus laevis
460917 Pan troglodytes
488118 Canis lupus familiaris
707775 Macaca mulatta
100068164 Equus caballus
100101928 Sus scrofa
100124955 Xenopus (Silurana) tropicalis
100328965 Oryctolagus cuniculus
100230686 Taeniopygia guttata
100598391 Nomascus leucogenys
286819 Bos taurus
395232 Gallus gallus
406760 Danio rerio
100173892 Pongo abelii
100729485 Cavia porcellus
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