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FAL1 may work as a ceRNA to modulate AKT1 expression via competitively binding to miR-637 in HSCR.
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we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the colorectal cancer cell proliferation
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High EIF4A expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.
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MYC, DUX4, and EIF4A3 might contribute to facioscapulohumeral dystrophy pathophysiology
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Host eIF4AIII RNA helicase is required for efficient human cytomegalovirus replication.
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EIF4A3 is a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis. Richieri-Costa-Pereira syndrome is caused by mutations in EIF4A3.
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The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins.
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CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
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demonstrate direct physical interactions between yeast Sgd1p and Fal1p, and between their human orthologs (NOM1 and eIF4AIII) in vitro and in vivo, identifying human NOM1 as a missing eIF4G-like interacting partner of eIF4AIII
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identification of eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay in mammals
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eIF4AIII represents a new functional class of DExH/D box proteins that act as RNA clamps or 'place holders' for the sequence-independent attachment of additional factors to RNAs.
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detection of autoantibodies to DDX48 may have clinical utility for the improved diagnosis of pancreatic cancer
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The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14.
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crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic
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Although it is dispensable for pre-mRNA splicing in vitro, eIF4A3 is required for splicing-dependent loading of the Y14-Magoh core heterodimer onto mRNA.
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Data show that eIF4AIII, a core exon junction complex (EJC) component loaded onto mRNAs by pre-mRNA splicing, is associated with neuronal mRNA granules and dendritic mRNAs.
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The nonsense-mediated-decay mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.
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NMP 265, a common part of the nuclear matrix, is located in the nucleus via an N-terminal amino acid sequence.
