anti-Eukaryotic Translation Initiation Factor 4E (EIF4E) Antibodies

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Proteins (16) and EIF4E Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074
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Top anti-EIF4E Antibodies at antibodies-online.com

Showing 10 out of 267 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p), WB 100 μL Log in to see 3 to 7 Days
$306.90
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-EIF4E Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain <b>Sample Type:</b> Lane1 = 10ug HEK293 lysate<br>Lane 2 = 50ug HEK293 lysate<br><b>Primary Antibody Dilution:</b> Anti-EIF4E 1:1000<br><b>Submitted By</b>: Dr. Veronique Dorval, Laval University 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Eif4e AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Rat Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry: eIF4E [p Ser209] Antibody [ABIN43076388] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using elF4E (phospho-Ser209) antibody Western Blot: eIF4E [p Ser209] Antibody [ABIN43076388] - Analysis of extract from NIH/3T3 cells untreated or treated with 10% serum (15min), using elF4E (Ab-209) antibody ( Line 1 and 2) and elF4E (phospho-Ser209) antibody (Line 3 and 4). 0.05 mL Log in to see 12 to 15 Days
$415.44
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-EIF4E Antibody (N-term) Pab (ABIN388675) in HL60 cell line lysates. EIF4E Antibody (N-term)(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with EIF4E antibody (N-term)(ABIN388675), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: eIF4E Antibody (5D11) [NBP2-22177] - Immunohistochemical analysis of paraffin-embedded stomach cancer (left) and prostate cancer (right) using eIF4E mouse mAb with DAB staining. Immunohistochemistry-Paraffin: eIF4E Antibody (5D11) [NBP2-22177] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-eIF4E mouse monoclonal antibody. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of EIF4E staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of EIF4E expression in HEK293T (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-EIF4E-pS209 Phospho-specific Pab (ABIN389859) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with Anisomycin 25ug/ml 30', using eIF4E (Phospho-Ser209) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using eIF4E (Phospho-Ser209) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

EIF4E Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-EIF4E Antibodies

  1. Human Monoclonal EIF4E Primary Antibody for FACS, WB - ABIN659031 : Hoeffer, Cowansage, Arnold, Banko, Moerke, Rodriguez, Schmidt, Klosi, Chorev, Lloyd, Pierre, Wagner, LeDoux, Klann: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal EIF4E Primary Antibody for ICC, FACS - ABIN969094 : Slepenkov, Korneeva, Rhoads: Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal EIF4E Primary Antibody for FACS, IF - ABIN966052 : Holm, Byrnes, Johnson, Abreo, Sehon, Alley, Meschonat, Md, Li: A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer. in Annals of surgical oncology 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal EIF4E Primary Antibody for ICC, IF - ABIN4307638 : Chen, Zhu, McCauley, Zhao, Johnson, Rhoads, El-Kadi: Diminished satellite cell fusion and S6K1 expression in myotubes derived from skeletal muscle of low birth weight neonatal pigs. in Physiological reports 2017 (PubMed)

  5. Human Monoclonal EIF4E Primary Antibody for IF, WB - ABIN659032 : Hoeffer, Santini, Ma, Arnold, Whelan, Wong, Pierre, Pelletier, Klann: Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. in Journal of neurophysiology 2013 (PubMed)

More Antibodies against EIF4E Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. The structures of eIF4E-eIF4G (show EIF4G1 Antibodies) complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (show EIF4EBP1 Antibodies) impairs the competition with eIF4G (show EIF4G1 Antibodies) for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 (show EIF4E3 Antibodies) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (show EIF4EBP1 Antibodies) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (show PARK2 Antibodies) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (show MAPK1 Antibodies) and is activated by ERK (show MAPK1 Antibodies) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 Antibodies), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Maize/Corn (Zea mays) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Pumilio 2 (show PUM2 Antibodies) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (show CDK1 Antibodies) and calcineurin regulate Maskin (show TACC3 Antibodies) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (show EIF4ENIF1 Antibodies) and eIF4E1b (show EIF4E1B Antibodies)

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. The findings suggest that AEG-1 (show MTDH Antibodies) promotes gastric cancer metastasis through upregulation of eIF4E-mediated MMP-9 (show MMP9 Antibodies) and Twist.

  2. The authors show that the eukaryotic translation initiation factor (show EIF2A Antibodies) eIF4E, an oncoprotein, drives hyaluronan biosynthesis. eIF4E stimulates production of enzymes that synthesize the building blocks of hyaluronan, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as well as hyaluronic acid synthase which forms the disaccharide chain.

  3. The present study indicated that miR (show MLXIP Antibodies)-15a downregulation was associated with cell proliferation and invasion by directly targeting eIF4E during RCC (show XRCC1 Antibodies) progression.

  4. High expressions of eIF-4E are associated with advanced stage and poor prognosis.

  5. Our results indicate that AURKA (show AURKA Antibodies) plays an important role in the activation of EIF4E and cap-dependent translation. Targeting the AURKA (show AURKA Antibodies)-EIF4E-c-MYC (show MYC Antibodies) axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA (show AURKA Antibodies) and activation of EIF4E and c-MYC (show MYC Antibodies)

  6. Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA (show PCNA Antibodies) and eIF4E. Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 (show TP53 Antibodies) and p21 (show CDKN1A Antibodies), and the reduction of PCNA (show PCNA Antibodies) and eIF4E expression levels.

  7. eIF4E and MMP9 (show MMP9 Antibodies) expression in endometrial cancer specimens suggests their potential up-regulation during carcinogenesis.

  8. eIF4E promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C (show VEGFC Antibodies), MMP-2 (show MMP2 Antibodies) and suppressing E-cadherin (show CDH1 Antibodies) expression.

  9. Translational initiation pathway inhibition could be of clinical utility in male breast cancer patients overexpressing eIF4E and eIF5 (show EIF5 Antibodies). With mTOR (show FRAP1 Antibodies) inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required

  10. Data show association of eIF4E expression with chemotherapeutic response in esophageal squamous cell carcinoma (ESCC), and suggest that therapeutically targeting eIF4E may be a viable means of improving chemotherapy response in ESCC.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Lack of Def6 (show DEF6 Antibodies) results in deregulation of Bcl6 (show BCL6 Antibodies) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E axis.

  2. Mitogen-activated protein kinase (show MAPK1 Antibodies) interacting protein (show CIB1 Antibodies) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (show FRAP1 Antibodies) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (show EIF4EBP1 Antibodies), to release translational repression.

  3. PRMT1 (show PRMT1 Antibodies) inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5 (show PRMT5 Antibodies).

  4. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  5. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Antibodies)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  6. Results of our study suggest that the eIF4E/Fmr1 (show FMR1 Antibodies) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  7. Our findings identify the eIF4E- beta-catenin (show CTNNB1 Antibodies) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  8. Unphosphorylated HSP27 (show HSPB1 Antibodies) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  9. Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Antibodies)-mediated S6K1 (show RPS6KB1 Antibodies) and 4E-BP1 (show EIF4EBP1 Antibodies)/eIF4E pathways, resulting in caspase (show CASP3 Antibodies)-dependent and -independent apoptosis in neuronal cells.

  10. Findings indicate eIF4E is maintained at levels in excess (show RCC1 Antibodies) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 Antibodies) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 Antibodies) and degradation of 4E-BP1 (show EIF4EBP1 Antibodies) and/or truncation of 4E-BP2 (show EIF4EBP2 Antibodies) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 Antibodies) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 Antibodies) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen Profile

Protein Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) antibody
  • eucaryotic initiation factor 6 (eif6) antibody
  • eukaryotic translation initiation factor 4E (eif4e) antibody
  • eukaryotic translation initiation factor 4E family member 1B S homeolog (eif4e1b.S) antibody
  • eukaryotic translation initiation factor 4E (EIF4E) antibody
  • eukaryotic translation initiation factor 4E (Eif4e) antibody
  • eukaryotic translation initiation factor 4E L homeolog (eif4e.L) antibody
  • eukaryotic translation initiation factor 4ea (eif4ea) antibody
  • translation initiation factor eIF4E (LOC100533326) antibody
  • 2 antibody
  • 0260/09 antibody
  • 0587/11 antibody
  • 0589/11 antibody
  • 0919/12 antibody
  • 1004/13 antibody
  • 7238 antibody
  • AUTS19 antibody
  • cbp antibody
  • CG4035 antibody
  • CT13384 antibody
  • CT39424 antibody
  • CT39426 antibody
  • D-eIF4E antibody
  • deIF-4E antibody
  • deIF4E antibody
  • Dmel\\CG4035 antibody
  • EG668879 antibody
  • EIF-4E antibody
  • eIF-4E1 antibody
  • eIF-4E2 antibody
  • eIF-4EII antibody
  • eif4e antibody
  • eIF 4E antibody
  • eif4e-1 antibody
  • eIF4E-1/2 antibody
  • eIF4E-2 antibody
  • Eif4e-ps antibody
  • EIF4E1 antibody
  • eIF4EI antibody
  • EIF4EL1 antibody
  • EIF4F antibody
  • If4e antibody
  • l(3)07238 antibody
  • l(3)67Af antibody
  • l(3)S025007 antibody
  • l(3)S026009 antibody
  • l(3)S058711 antibody
  • l(3)S091912 antibody
  • zgc:86680 antibody

Protein level used designations for EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPECIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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