Eukaryotic Translation Initiation Factor 4E (EIF4E) ELISA Kits

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Antibodies (273) and EIF4E Proteins (17) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
EIF4E 1977 P06730
Anti-Mouse EIF4E EIF4E 13684 P63073
Anti-Rat EIF4E EIF4E 117045 P63074
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More ELISA Kits for EIF4E Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (show EIF4EBP1 ELISA Kits) impairs the competition with eIF4G for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (show EIF4EBP1 ELISA Kits) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (show PARK2 ELISA Kits) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (show MAPK1 ELISA Kits) and is activated by ERK (show MAPK1 ELISA Kits) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 ELISA Kits), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Maize/Corn (Zea mays) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (show CDK1 ELISA Kits) and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Our study...suggests that methylation of cg11037477 and expression of EIF4E may act as prognostic markers in gastric cancer

  2. Lack of regulation of the interaction between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer. The inhibitor 4EGI-1 binds to eIF4E, thereby preventing association with eIF4G through an allosteric mechanism. Binding of 4EGI-1 perturbs native correlated motions and increases correlated fluctuations in part of the eIF4G binding site.

  3. The findings suggest that AEG-1 (show MTDH ELISA Kits) promotes gastric cancer metastasis through upregulation of eIF4E-mediated MMP-9 (show MMP9 ELISA Kits) and Twist.

  4. The authors show that the eukaryotic translation initiation factor (show EIF2A ELISA Kits) eIF4E, an oncoprotein, drives hyaluronan biosynthesis. eIF4E stimulates production of enzymes that synthesize the building blocks of hyaluronan, UDP-Glucuronic acid and UDP-N-Acetyl-Glucosamine, as well as hyaluronic acid synthase which forms the disaccharide chain.

  5. The present study indicated that miR (show MLXIP ELISA Kits)-15a downregulation was associated with cell proliferation and invasion by directly targeting eIF4E during RCC (show XRCC1 ELISA Kits) progression.

  6. High expressions of eIF-4E are associated with advanced stage and poor prognosis.

  7. Our results indicate that AURKA (show AURKA ELISA Kits) plays an important role in the activation of EIF4E and cap-dependent translation. Targeting the AURKA (show AURKA ELISA Kits)-EIF4E-c-MYC (show MYC ELISA Kits) axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA (show AURKA ELISA Kits) and activation of EIF4E and c-MYC (show MYC ELISA Kits)

  8. Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA (show PCNA ELISA Kits) and eIF4E. Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 (show TP53 ELISA Kits) and p21 (show CDKN1A ELISA Kits), and the reduction of PCNA (show PCNA ELISA Kits) and eIF4E expression levels.

  9. eIF4E and MMP9 (show MMP9 ELISA Kits) expression in endometrial cancer specimens suggests their potential up-regulation during carcinogenesis.

  10. eIF4E promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C (show VEGFC ELISA Kits), MMP-2 (show MMP2 ELISA Kits) and suppressing E-cadherin (show CDH1 ELISA Kits) expression.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. eIF4E availability and phosphorylation promote metastasis in mouse models of breast cancer by selectively augmenting the translation of mRNAs involved in invasion and metastasis.

  2. Lack of Def6 results in deregulation of Bcl6 (show BCL6 ELISA Kits) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E axis.

  3. Mitogen-activated protein kinase (show MAPK1 ELISA Kits) interacting protein (show CIB1 ELISA Kits) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (show FRAP1 ELISA Kits) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (show EIF4EBP1 ELISA Kits), to release translational repression.

  4. PRMT1 inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5.

  5. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  6. data suggest a physiological role for MNK1a-Ser (show SIGLEC1 ELISA Kits)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  7. Results of our study suggest that the eIF4E/Fmr1 (show FMR1 ELISA Kits) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  8. Our findings identify the eIF4E- beta-catenin (show CTNNB1 ELISA Kits) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  9. Unphosphorylated HSP27 (show HSPB1 ELISA Kits) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  10. Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 ELISA Kits)-mediated S6K1 (show RPS6KB1 ELISA Kits) and 4E-BP1 (show EIF4EBP1 ELISA Kits)/eIF4E pathways, resulting in caspase (show CASP3 ELISA Kits)-dependent and -independent apoptosis in neuronal cells.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 ELISA Kits) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F and degradation of 4E-BP1 and/or truncation of 4E-BP2 that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 ELISA Kits) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 ELISA Kits) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen Profile

Antigen Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) antibody
  • eucaryotic initiation factor 6 (eif6) antibody
  • eukaryotic translation initiation factor 4E (eif4e) antibody
  • eukaryotic translation initiation factor 4E family member 1B S homeolog (eif4e1b.S) antibody
  • eukaryotic translation initiation factor 4E (EIF4E) antibody
  • eukaryotic translation initiation factor 4E (Eif4e) antibody
  • eukaryotic translation initiation factor 4E L homeolog (eif4e.L) antibody
  • eukaryotic translation initiation factor 4ea (eif4ea) antibody
  • translation initiation factor eIF4E (LOC100533326) antibody
  • 2 antibody
  • 0260/09 antibody
  • 0587/11 antibody
  • 0589/11 antibody
  • 0919/12 antibody
  • 1004/13 antibody
  • 7238 antibody
  • AUTS19 antibody
  • cbp antibody
  • CG4035 antibody
  • CT13384 antibody
  • CT39424 antibody
  • CT39426 antibody
  • D-eIF4E antibody
  • deIF-4E antibody
  • deIF4E antibody
  • Dmel\\CG4035 antibody
  • EG668879 antibody
  • EIF-4E antibody
  • eIF-4E1 antibody
  • eIF-4E2 antibody
  • eIF-4EII antibody
  • eif4e antibody
  • eIF 4E antibody
  • eif4e-1 antibody
  • eIF4E-1/2 antibody
  • eIF4E-2 antibody
  • Eif4e-ps antibody
  • EIF4E1 antibody
  • eIF4EI antibody
  • EIF4EL1 antibody
  • EIF4F antibody
  • If4e antibody
  • l(3)07238 antibody
  • l(3)67Af antibody
  • l(3)S025007 antibody
  • l(3)S026009 antibody
  • l(3)S058711 antibody
  • l(3)S091912 antibody
  • zgc:86680 antibody

Protein level used designations for EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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