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FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXO32 Antibodies (88) and FBXO32 Kits (30) and many more products for this protein.
Showing 9 out of 9 products:
Human FBXO32 Protein expressed in Wheat germ - ABIN1353808
Lokireddy, McFarlane, Ge, Zhang, Sze, Sharma, Kambadur: Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. in Molecular endocrinology (Baltimore, Md.) 2011
Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.
Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.
F-box only protein 32 (FBXO32) directly ubiquitinates C-terminal binding protein 1 (CtBP1 (show CTBP1 Proteins)), which is required for its stability and nuclear retention.
Authors found that the FBXO32 and SMAD4 (show SMAD4 Proteins) levels were higher in normal tissues than in CRC (show CALR Proteins) tissues. The expressions of FBXO32 and SMAD4 (show SMAD4 Proteins) were related to clinicopathological parameters in CRC (show CALR Proteins).
role of the muscle specific (show EIF3K Proteins) E3s MuRF-1 (show TRIM63 Proteins) and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review)
FBXO32 activates NF-kappaB (show NFKB1 Proteins) through IkappaBalpha (show NFKBIA Proteins) degradation in inflammatory and genotoxic stress
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (show MUL1 Proteins) FBXO32/atrogin-1 and its transcription factor FOXO3A (show FOXO3 Proteins).
Low FBXO32 expression is associated with breast cancer tumorigenesis.
the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system
These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.
Our results indicate that abnormal SCF (show KITLG Proteins) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .
Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.
we speculated that the overexpression of FBXO32 is responsible for congenital splay leg syndrome and it plays an important role in the PI3K-Akt (show AKT1 Proteins) pathway
this study shows that aspartate suppresses lipopolysaccharide-induced MAFbx expression in skeletal muscle via activation of Akt (show AKT1 Proteins) signaling, and inhibition of AMPKa and FOXO1 (show FOXO1 Proteins) signaling
Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (show C5orf13 Proteins) is of potential in the diagnosis of subclinical PCS.
A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.
Oligonol-mediated downregulation of Atrogin-1 and MuRF1 (show TRIM63 Proteins) gene expression alleviates muscle loss and improves the impaired myotube formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss.
Indoxyl sulfate enhanced the production of atrogin-1 by enhancing oxidative stress in skeletal muscle, leading to muscle atrophy.
Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta (show CEBPB Proteins) binding to atrogin1 promoter locus in the myotubes.
educed PABPN1 levels caused a consistent decline in distal PAS utilization in the 3'-UTR of a subset of OPMD-dysregulated genes. This alternative PAS utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 levels caused a reduction in proteasomal activity, and transition in MyHC isotope expression pattern in myofibers.
Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (show MUL1 Proteins) mediated by the reduction of Akt (show AKT1 Proteins)-FOXO3a (show FOXO3 Proteins) signaling by oxidative stress.
MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 (show TRIM63 Proteins) mRNA expression was less affected by ageing
Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.
Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (show TNF Proteins) induced atrophy.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
F-box only protein 32
, F-box protein 32
, F-box only protein 32-like
, atrogin 1
, muscle atrophy F-box protein
, atrophy gene 1