F-Box Protein 4 (FBXO4) ELISA Kits

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 4 Antibodies (93) and F-Box Protein 4 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  
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Top F-Box Protein 4 ELISA Kits at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Rat 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Human 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Sheep
  96 Tests 15 to 18 Days
$707.14
Details
Guinea Pig
  96 Tests 15 to 18 Days
$707.14
Details
Pig
  96 Tests 15 to 18 Days
$707.14
Details
Chicken
  96 Tests 15 to 18 Days
$707.14
Details
Goat
  96 Tests 15 to 18 Days
$707.14
Details
Rabbit
  96 Tests 15 to 18 Days
$707.14
Details
Monkey
  96 Tests 15 to 18 Days
$707.14
Details

More ELISA Kits for F-Box Protein 4 Interaction Partners

Human F-Box Protein 4 (FBXO4) interaction partners

  1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels.

  2. FBXO4 is the E3 ubiquitin ligase to interact with and promote Mcl-1 ubiquitination and degradation.

  3. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in human cancers.

  4. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  5. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  6. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  7. results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control

  8. Fbx4 is a central regulator of Pin2/TRF1 protein abundance and alterations in the stability of Pin2/TRF1 can have a dramatic impact on telomere length

  9. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1.

  10. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 deregulation and nuclear accumulation

  4. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1.

  5. Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase.

F-Box Protein 4 (FBXO4) Antigen Profile

Antigen Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with F-Box Protein 4 (FBXO4) ELISA Kits

  • F-box protein 4 (FBXO4) antibody
  • F-box protein 4 (Fbxo4) antibody
  • F-box protein 4 (fbxo4) antibody
  • F-box protein 4 L homeolog (fbxo4.L) antibody
  • 1700096C12Rik antibody
  • AI851261 antibody
  • AW494535 antibody
  • fbx4 antibody
  • FBXO4 antibody
  • si:dkey-46a10.2 antibody

Protein level used designations for F-Box Protein 4 (FBXO4) ELISA Kits

F-box only protein 4 , F-box protein Fbx4 , F-box protein 4 , F-box only protein 4-like

GENE ID SPECIES
26272 Homo sapiens
106052 Mus musculus
310363 Rattus norvegicus
431586 Gallus gallus
489220 Canis lupus familiaris
534852 Bos taurus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
101116349 Ovis aries
100735926 Cavia porcellus
100319387 Danio rerio
100522958 Sus scrofa
100856557 Canis lupus familiaris
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