anti-F-Box Protein 43 (FBXO43) Antibodies

Human F-Box Protein 43 (FBXO43) interaction partners

1. The mutation in FBXO43 is a causative factor of male infertility and teratozoospermia.

2. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition

Mouse (Murine) F-Box Protein 43 (FBXO43) interaction partners

1. besides regulating cell-cycle arrest in mouse eggs, Emi2 is essential for meiosis I progression in spermatocytes. In the absence of Emi2, spermatocytes arrest in early diplotene of prophase I.

2. Data suggest that the increase of Wee 1 tyrosine kinase but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs.

3. These results suggest that in addition to the Mos-MEK1/2 pathway, the Mos-mediated p38 pathway may be implicated in metaphase-II arrest.

4. data support the conclusion that zinc itself, through its interaction with EMI2, is a central component of the cytostatic factor

5. phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggest that mouse MSK1 may play a key role in the metaphase-II arrest through phosphorylation of EMI2

6. separable N- and C-terminal domains of mouse Emi2 modulated metaphase establishment and maintenance, respectively, through indirect and direct mechanisms.

7. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition

Xenopus laevis F-Box Protein 43 (FBXO43) interaction partners

1. CaN contributes to timely APC/C activation at fertilization by both negatively regulating the APC/C inhibitory activity of XErp1 and positively regulating the APC/C-activating function of Cdc20.

2. the APC/C-inhibitory activity of XErp1 (also known as Emi2) was essential for early divisions in Xenopus embryos.

3. Thus, Mos and Erp1 collaboratively establish and maintain metaphase II arrest in Xenopus eggs

4. Emi2 stability and activity are dynamically regulated by Emi2-bound multiple kinases and PP2A phosphatase.

5. Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes.

6. Emi2 directs meiosis II-specific cytostatic factor cell cycle arrest.

7. Emi2/XErp1 is the critical cytostatic factor component directly responsible for anaphase-promoting complex/cyclosome inhibition during CSF arrest.

8. These findings provide a novel mechanism of APC/C inhibition wherein the final step of ubiquitin transfer is targeted and raise the interesting possibility that APC/C is inhibited by Emi2 in a catalytic manner.

9. Data show that Emi2 binds the anaphase-promoting complex/cyclosome via the C-terminal tail.

10. review mechanism of action and mode of regulation of Emi2, CSF function, and the general principles of APC/C regulation and control of protein function by MAPK pathways [review]