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Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif.
Showing 3 out of 3 products:
Cdc2 (show CDK1 Proteins) and Mos (show MOS Proteins) regulate Emi2 stability to promote the meiosis I-meiosis II transition
besides regulating cell-cycle arrest in mouse eggs, Emi2 is essential for meiosis I progression in spermatocytes. In the absence of Emi2, spermatocytes arrest in early diplotene of prophase I.
Data suggest that the increase of Wee 1 (show WEE1 Proteins) tyrosine kinase (show TYRO3 Proteins) but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF (show MSLN Proteins)) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs.
These results suggest that in addition to the Mos (show MOS Proteins)-MEK1 (show MAP2K1 Proteins)/2 pathway, the Mos (show MOS Proteins)-mediated p38 (show CRK Proteins) pathway may be implicated in metaphase-II arrest.
data support the conclusion that zinc itself, through its interaction with EMI2, is a central component of the cytostatic factor
phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggest that mouse MSK1 (show RPS6KA5 Proteins) may play a key role in the metaphase-II arrest through phosphorylation of EMI2
separable N- and C-terminal domains of mouse Emi2 modulated metaphase establishment and maintenance, respectively, through indirect and direct mechanisms.
the APC (show APC Proteins)/C-inhibitory activity of XErp1 (also known as Emi2) was essential for early divisions in Xenopus embryos.
Thus, Mos (show MOS Proteins) and Erp1 collaboratively establish and maintain metaphase II arrest in Xenopus eggs
Emi2 stability and activity are dynamically regulated by Emi2-bound multiple kinases and PP2A (show PPP2R2B Proteins) phosphatase.
Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes.
Emi2 directs meiosis II-specific cytostatic factor cell cycle arrest.
Emi2/XErp1 is the critical cytostatic factor component directly responsible for anaphase-promoting complex/cyclosome inhibition during CSF (show CSF2 Proteins) arrest.
These findings provide a novel mechanism of APC (show APC Proteins)/C inhibition wherein the final step of ubiquitin transfer is targeted and raise the interesting possibility that APC (show APC Proteins)/C is inhibited by Emi2 in a catalytic manner.
Data show that Emi2 binds the anaphase-promoting complex/cyclosome via the C-terminal tail.
review mechanism of action and mode of regulation of Emi2, CSF (show CSF2 Proteins) function, and the general principles of APC (show APC Proteins)/C regulation and control of protein function by MAPK (show MAPK1 Proteins) pathways [review]
Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box only protein 43
, early mitotic inhibitor 2
, endogenous meiotic inhibitor 2
, XErp1 homolog
, F-box protein 43
, F-box only protein 43-like
, f-box only protein 43-like
, F-box protein 26
, emi1-related protein 1