More product categories related to F-Box Protein 7 ELISA Kit
More ELISA Kits for F-Box Protein 7 Interaction Partners
Zebrafish F-Box Protein 7 (FBXO7) interaction partners
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analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons
Human F-Box Protein 7 (FBXO7) interaction partners
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Results suggest that FBXO7 gene doesn't seem to be a risk factor to develop sporadic Parkinson's disease in Chinese population.
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The pathological mechanisms concerning FBXO7-relevant protein aggregation, mitochondria impairment, reactive oxygen species (ROS) generation and mitophagy modulation in PARK15 pathogenesis are highlighted and discussed in the current review.
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we highlight the recent research on FBXO7, which advances our knowledge of the etiopathological pathways and fills unexpected gaps therein, justifying the dedicated study of rare variants of Parkinson disease--{REVIEW}
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Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain.
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Structure and function of Fbxo7 in Parkinson's disease has been summarized. (Review)
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Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
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Mutations in the F-box only protein 7 (FBXO7) gene, located on chromosome 22q12-q13, have been identified as having distinct clinical features in patients with hereditary Parkinson's disease (PD).
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The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with autosomal recessive juvenile-onset Parkinson's disease We demonstrated wild-type FBXO7 is a stress response protein with both cytoprotective and neurotoxic roles
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This is first time a FBXO7 mutation has been identified that causes phenotype compatible with typical idiopathic Parkinson's disease and presents with some of its common nonmotor features
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High expression of PARK15 might lead to the occurrence of non-small-cell lung cancer.
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genetic analysis of this Turkish family and the Italian PARK15 family reported previously revealed that the c.1492C > T mutation is present on two different haplotypes in the Italian family
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in addition to the parkinsonian-pyramidal phenotype, in connection with FBXO7 mutations and points to an intrafamilial phenotypic variation
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Cys52 variant of FBXO7 may contribute to reduced Parkinson's disease susceptibility in Chinese
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The involvement of the FBXO7 gene in PD is very rare, at least in this population from southern Spain.
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The crystal structure of the Fbxo7 FP domain is reported at 2.0 A resolution. The Fbxo7 FP domain adopts an alpha/beta-fold similar to that of the PI31 FP domain.
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A mutational analysis of the FBXO7 gene in Taiwanese patients with Parkinson's disease (PD) does not show a potential pathophysiological role in PD.
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This study showed that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy.
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An important role is suggested for FBXO7 in the pathogenesis of synucleinopathies, including Parkinson's disease and multiple system atrophy.
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Mutations in FBX07 is often associated with rapidly progressive parkinsonism and with additional features including pyramidal signs, cognitive decline and loss of sustained Levodopa responsiveness.
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analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons
Mouse (Murine) F-Box Protein 7 (FBXO7) interaction partners
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Fbxo7 hypomorphs were produced at a normal Mendelian ratio with a normal lifespan and no evidence of neurological symptoms. These data suggest that erythrocyte survival, T cell development and spermatogenesis are particularly sensitive to Fbxo7 gene dosage.
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Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.
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Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.
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Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 expression.
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2 PDX models showed gained mutations such as PIK3CA or FBWX7 mutation. Ten patient-derived advanced colon cancer xenograft models were established.
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The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells.
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Fbxo7 specifically regulated D cyclin/cdk6 complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers.
F-Box Protein 7 (FBXO7) Antigen Profile
Antigen Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
Gene names and symbols associated with F-Box Protein 7 (FBXO7) ELISA Kits
- F-box protein 7 (FBXO7) antibody
- F-box protein 7 L homeolog (fbxo7.L) antibody
- F-box protein 7 (fbxo7) antibody
- F-box protein 7 (FBP7) antibody
- F-box protein 7 (Fbxo7) antibody
- 2410015K21Rik antibody
- A230052G17Rik antibody
- AI117679 antibody
- ATFBP7 antibody
- AW260462 antibody
- C85118 antibody
- DKFZp469H0739 antibody
- F-box protein 7 antibody
- F8K7.20 antibody
- F8K7_20 antibody
- FBX antibody
- FBX07 antibody
- FBX7 antibody
- FBXO7 antibody
- MGC80085 antibody
- MGC135804 antibody
- MGC145325 antibody
- PARK15 antibody
- PKPS antibody
- si:ch211-286m4.2 antibody
- zgc:114096 antibody
Protein level used designations for F-Box Protein 7 (FBXO7) ELISA Kits
F-box only protein 7 , F-box protein 7 , F-box only protein 7-like
GENE ID | SPECIES |
---|---|
418063 | Gallus gallus |
474522 | Canis lupus familiaris |
446503 | Xenopus laevis |
470266 | Pan troglodytes |
717317 | Macaca mulatta |
780025 | Xenopus (Silurana) tropicalis |
838780 | Arabidopsis thaliana |
100016137 | Monodelphis domestica |
100135459 | Papio anubis |
100172444 | Pongo abelii |
100409679 | Callithrix jacchus |
100595350 | Nomascus leucogenys |
558097 | Danio rerio |
25793 | Homo sapiens |
100155281 | Sus scrofa |
508235 | Bos taurus |
100328739 | Oryctolagus cuniculus |
69754 | Mus musculus |
366854 | Rattus norvegicus |
101118684 | Ovis aries |
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