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FBXO7 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 7 Antibodies (27) and F-Box Protein 7 Kits (12) and many more products for this protein.
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analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons
Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain.
Structure and function of Fbxo7 in Parkinson's disease has been summarized. (Review)
Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
Mutations in the F-box only protein 7 (FBXO7) gene, located on chromosome 22q12-q13, have been identified as having distinct clinical features in patients with hereditary Parkinson's disease (PD).
The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with autosomal recessive juvenile-onset Parkinson's disease We demonstrated wild-type FBXO7 is a stress response protein with both cytoprotective and neurotoxic roles
This is first time a FBXO7 mutation has been identified that causes phenotype compatible with typical idiopathic Parkinson's disease and presents with some of its common nonmotor features
High expression of PARK15 might lead to the occurrence of non-small-cell lung cancer.
genetic analysis of this Turkish family and the Italian PARK15 family reported previously revealed that the c.1492C > T mutation is present on two different haplotypes in the Italian family
in addition to the parkinsonian-pyramidal phenotype, in connection with FBXO7 mutations and points to an intrafamilial phenotypic variation
Cys52 variant of FBXO7 may contribute to reduced Parkinson's disease susceptibility in Chinese
Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Proteins) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (show CDKN1B Proteins) levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.
Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.
Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 (show CDKN1B Proteins) expression.
2 PDX models showed gained mutations such as PIK3CA (show PIK3CA Proteins) or FBWX7 mutation. Ten patient-derived advanced colon cancer xenograft models were established.
The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells.
Fbxo7 specifically regulated D cyclin (show PCNA Proteins)/cdk6 (show CDK6 Proteins) complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
F-box only protein 7
, F-box protein 7
, F-box only protein 7-like