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FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. Additionally we are shipping FAN1 Kits (4) and and many more products for this protein.
Showing 10 out of 35 products:
Human Polyclonal FAN1 Primary Antibody for IF, WB - ABIN524848
Sareen, Chaudhury, Adams, Sobeck: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. in Nucleic acids research 2012
hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap (show ALOX5AP Antibodies) cleavage.
FAN1 (show FSCN1 Antibodies) interaction with ubiquitylated PCNA (show PCNA Antibodies) alleviates replication stress and preserves genomic integrity independently of BRCA2 (show BRCA2 Antibodies)
The structures, function, and proposed mechanisms of FAN1 (show FSCN1 Antibodies) nuclease (show DCLRE1C Antibodies) are discussed, and the insights into its role in interstrand cross-links repair and in processing of stalled replication forks are provided. [REVIEW]
show that DNA repair genes (fan1 (show FSCN1 Antibodies) and pms2 (show PMS2 Antibodies)) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats
FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.
EXO1 (show EXO1 Antibodies) and FEN1 (show FEN1 Antibodies) cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP Antibodies) and the duplex, whereas FAN1 (show FSCN1 Antibodies) incised it three to four nucleotides in the double-stranded region.
Detected FAN1 (show FSCN1 Antibodies) mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.
The crystal structures of human FAN1 (show FSCN1 Antibodies) in complex with a 5' flap (show ALOX5AP Antibodies) DNA substrate show that two FAN1 (show FSCN1 Antibodies) molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap (show ALOX5AP Antibodies) for subsequent incision.
In this work, FAN1 (show FSCN1 Antibodies)-DNA crystal structures and biochemical data reveal that human FAN1 (show FSCN1 Antibodies) cleaves DNA successively at every third nucleotide
Results show that FAN1 (show FSCN1 Antibodies) utilizes its nuclease (show DCLRE1C Antibodies) activity-in cooperation with the BLM (show BLM Antibodies)-FANCD2 (show FANCD2 Antibodies) complex-to promote replication fork restart and simultaneous suppression of new origin firing.
Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease
Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy
ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.
Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.
This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.
coiled-coil domain-containing protein MTMR15
, fanconi anemia associated nuclease 1
, fanconi-associated nuclease 1
, myotubularin-related protein 15
, myotubularin related protein 15
, Fanconi-associated nuclease 1