anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) Antibodies

FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. Additionally we are shipping FAN1 Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FAN1 22909 Q9Y2M0
Anti-Mouse FAN1 FAN1 330554 Q69ZT1
Anti-Rat FAN1 FAN1 309256  
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Top anti-FAN1 Antibodies at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: MTMR15 Antibody [NBP1-42677] - FFPE section of human ovarian carcinoma. Antibody used at a dilution of 1:250 Detection: DAB staining using Immunohistochemistry Accessory Kit. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated FACS, WB Western Blot at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis of MTMRF Antibody in K562 cell line lysates (35ug/lane) 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of KIAA1018 expression in transfected 293T cell line by KIAA1018 MaxPab polyclonal antibody.Lane 1: KIAA1018 transfected lysate(58.63 KDa).Lane 2: Non-transfected lysate. KIAA1018 MaxPab polyclonal antibody. Western Blot analysis of KIAA1018 expression in human spleen. 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IF, IHC, IHC (p), IP, WB   100 μL Log in to see 11 to 14 Days
$595.83
Details
Human Rabbit Un-conjugated IF, IHC, IHC (p)   100 μL Log in to see 11 to 14 Days
$625.17
Details
Human Rabbit Un-conjugated ELISA, FACS, WB   200 μL Log in to see 11 to 14 Days
$793.83
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: MTMR15 Antibody  - Staining of human cell line A-431 shows localization to nucleoplasm. 100 μL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Biotin FACS, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit HRP FACS, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details
Human Rabbit FITC FACS, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,013.83
Details

Top referenced anti-FAN1 Antibodies

  1. Human Polyclonal FAN1 Primary Antibody for IF, WB - ABIN524848 : Sareen, Chaudhury, Adams, Sobeck: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. in Nucleic acids research 2012 (PubMed)

More Antibodies against FAN1 Interaction Partners

Human FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap cleavage.

  2. FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

  3. The structures, function, and proposed mechanisms of FAN1 nuclease are discussed, and the insights into its role in interstrand cross-links repair and in processing of stalled replication forks are provided. [REVIEW]

  4. show that DNA repair genes (fan1 and pms2) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  5. FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.

  6. EXO1 and FEN1 cleaved the substrate at the boundary between the single-stranded 5' flap and the duplex, whereas FAN1 incised it three to four nucleotides in the double-stranded region.

  7. Detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.

  8. The crystal structures of human FAN1 in complex with a 5' flap DNA substrate show that two FAN1 molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap for subsequent incision.

  9. In this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA successively at every third nucleotide

  10. Results show that FAN1 utilizes its nuclease activity-in cooperation with the BLM-FANCD2 complex-to promote replication fork restart and simultaneous suppression of new origin firing.

  11. FAN1 encodes a DNA repair enzyme, thus implicating abnormalities in DNA repair in the susceptibility to schizophrenia or autism

  12. FAN1 might be a new mitotic substrate of APC/CCdh1 that plays a key role during mitotic exit.

  13. By exome sequencing, we identified mutations in FAN1 as a cause of karyomegalic interstitial nephritis, a disorder that serves as a model for renal fibrosis.

  14. Our results suggest that FAN1 has a minor role in interstrand crosslink repair compared with true Fanconi anemia genes and exclude FAN1 as a novel FA gene.

  15. Two FAN1 variants do not appear to be causal for breast cancer.

  16. Data show that FAN1 in DT40 cells participates in the processing of damage induced by interstrand cross-linking-generating agents also independently of the classical FA pathway.

  17. Data show that FAN1 is a nuclear protein and forms DNA-damage-induced foci, which appear to be at stalled replication forks as denoted by RPA colocalization.

  18. study characterizes FANI which promotes DNA interstrand cross-linking repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the FANCI-FANCD2 complex

  19. Study describes how a highly conserved protein, KIAA1018/MTMR15/FAN1, that interacts with, and is recruited to sites of DNA damage by, the monoubiquitinated form of FANCD2.

  20. KIAA1018 is a 5'-->3' exonuclease and a structure-specific endonuclease that preferentially incises 5' flaps; like cells from FA patients, human cells depleted of KIAA1018 are sensitized to ICL-inducing agents and display chromosomal instability.

Mouse (Murine) FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. FAN1 plays important role in protecting against somatic expansions but is either not involved in protecting against intergenerational repeat expansions or is redundant with other related enzymes.

  2. Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease

  3. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy

  4. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.

  5. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.

FAN1 Antigen Profile

Protein Summary

This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with FAN1

  • FANCD2 and FANCI associated nuclease 1 (FAN1) antibody
  • FANCD2/FANCI-associated nuclease 1 (Fan1) antibody
  • FANCD2/FANCI-associated nuclease 1 (fan1) antibody
  • FANCD2/FANCI-associated nuclease 1 (FAN1) antibody
  • FANCD2 and FANCI associated nuclease 1 (Fan1) antibody
  • 6030441H18Rik antibody
  • fi39f01 antibody
  • KIAA1018 antibody
  • KMIN antibody
  • mtmr15 antibody
  • RGD1566323 antibody
  • si:ch211-163b1.2 antibody
  • si:ch211-201b11.2 antibody
  • wu:fd06a07 antibody
  • wu:fi39f01 antibody

Protein level used designations for FAN1

coiled-coil domain-containing protein MTMR15 , fanconi anemia associated nuclease 1 , fanconi-associated nuclease 1 , myotubularin-related protein 15 , myotubularin related protein 15 , Fanconi-associated nuclease 1

GENE ID SPECIES
22909 Homo sapiens
330554 Mus musculus
565458 Danio rerio
100481860 Ailuropoda melanoleuca
415383 Gallus gallus
479017 Canis lupus familiaris
100154519 Sus scrofa
508171 Bos taurus
309256 Rattus norvegicus
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