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FAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. Additionally we are shipping and and many more products for this protein.
Showing 10 out of 53 products:
Human Polyclonal FAT1 Primary Antibody for IHC, IHC (p) - ABIN4310665
Morris, Kaufman, Gong, Ramaswami, Walsh, Turcan, Eng, Kannan, Zou, Peng, Banuchi, Paty, Zeng, Vakiani, Solit, Singh, Ganly, Liau, Cloughesy, Mischel, Mellinghoff, Chan: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. in Nature genetics 2013
Show all 6 Pubmed References
Human Polyclonal FAT1 Primary Antibody for IHC, IHC (p) - ABIN4310666
Caruso, Herberth, Bartoli, Puppo, Dumonceaux, Zimmermann, Denadai, Lebossé, Roche, Geng, Magdinier, Attarian, Bernard, Maina, Levy, Helmbacher: Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. in PLoS genetics 2013
Show all 2 Pubmed References
Study showed that FAT1 exhibits a high frequency of mutations and a downregulated expression in esophageal squamous cell carcinoma (ESCC) leading to cell migration and invasion by affecting the cellular mechanical properties of ESCC cells.
FAT1 has a novel regulatory effect on EMT (show ITK Antibodies)/stemness markers both via or independent of HIF-1alpha (show HIF1A Antibodies). The functional relevance of this study was corroborated by significant reduction in the number of soft-agar colonies formed in hypoxic-siFAT1 treated U87MG cells.
FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative head and neck squamous cell carcinoma; FAT1 mutation was significantly associated with better overall survival
Disruption of MAPK/ERK (show MAPK1 Antibodies) pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas.
Loss of function mutations in FAT1 and CASP8 (show CASP8 Antibodies) prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.
We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1 (show GPS1 Antibodies)) and FAT1
FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC (show CALR Antibodies).
Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1 (show SH3RF1 Antibodies)) protein interact with FAT1 protein.
At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha (show HIF1A Antibodies) was due to compromised EGFR (show EGFR Antibodies)-Akt (show AKT1 Antibodies) signaling as well as increased VHL (show VHL Antibodies)-dependent proteasomal degradation of HIF1alpha (show HIF1A Antibodies).
Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt (show WNT2 Antibodies) signaling pathway to exert its antitumor effect
The protection of fat-1 mice from UVB-induced skin inflammation was associated with decreased phosphorylation of STAT3 (show STAT3 Antibodies). Moreover, UVB-induced apoptosis was attenuated in fat-1 mouse skin.
Balanced diet-fed Fat-1 mice are able to preserve in part the soleus muscle mass, absolute isotonic force and cross-sectional area of the soleus muscle in a disuse condition.
studies suggest that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury. Given recent reports linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this Fat1 function may have importance in other settings of altered cell growth and metabolism
Fat1 deletion in podocytes induces abnormal glomerular filtration barrier development leading to podocyte foot process effacement. Fat1 knockdown in renal tubular cells reduces migration, decreases active RAC1 (show RAC1 Antibodies)/CDC42 (show CDC42 Antibodies) and induces defects in lumen formation.
Fat1 interacts with Fat4 (show FAT4 Antibodies) to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.
Fat-1 expression suppresses CD4+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin in bronchoalveolar lavage and lung tissues of mice.
Endogenous synthesis of n-3 PUFA in the fat-1 mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.
FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity
Data find that Fat1 and Fat4 (show FAT4 Antibodies) cooperate during mouse development to control renal tubular elongation, cochlear extension, cranial neural tube formation and patterning of outer hair cells in the cochlea.
results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development
these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described.
FAT tumor suppressor 1
, FAT tumor suppressor homolog 1
, cadherin ME5
, cadherin family member 7
, cadherin-related family member 8
, cadherin-related tumor suppressor homolog
, protein fat homolog
, protocadherin Fat 1
, fat 1 cadherin
, FAT tumor suppressor homolog 1 (Drosophila)
, protocadherin Fat 1-like