anti-FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Antibodies

FAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FAT1 2195 Q14517
FAT1 14107  
FAT1    
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Top anti-FAT Tumor Suppressor Homolog 1 (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: FAT1 Antibody [NBP1-84565] - Staining of human placenta shows strong cytoplasmic positivity in Decidual cells. Immunohistochemistry-Paraffin: FAT1 Antibody  - Staining of human rectum shows moderate cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis FAT1 using Jurkat whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC (p)   100 μL Log in to see 16 Days
$298.18
Details
Human Rabbit Un-conjugated WB Western Blot: FAT1 Antibody [NBP2-32274] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-FAT1 antibody NBP2-32274 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IF/ICC, WB 100 μg Log in to see 11 to 16 Days
$355.34
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human stomach with FAT1 polyclonal antibody  shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution. 100 μL Log in to see 11 to 12 Days
$460.00
Details
Human Rabbit Un-conjugated WB Western blot analysis FAT1 using Jurkat whole cell lysates. 100 μg Log in to see 11 to 16 Days
$454.83
Details
Fruit Fly Mouse Un-conjugated ELISA, ICC, IF, IHC, WB   0.1 mg Log in to see 7 to 9 Days
$345.00
Details
Human Rabbit Un-conjugated ICC, WB   100 μL Log in to see 13 to 16 Days
$500.28
Details
Human Rabbit Un-conjugated WB Western Blot: FAT1 Antibody [NBP2-32275] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-FAT1 antibody NBP2-32275 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$556.31
Details

Top referenced anti-FAT Tumor Suppressor Homolog 1 (Drosophila) Antibodies

  1. Human Polyclonal FAT1 Primary Antibody for IHC, IHC (p) - ABIN4310665 : Morris, Kaufman, Gong, Ramaswami, Walsh, Turcan, Eng, Kannan, Zou, Peng, Banuchi, Paty, Zeng, Vakiani, Solit, Singh, Ganly, Liau, Cloughesy, Mischel, Mellinghoff, Chan: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. in Nature genetics 2013 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal FAT1 Primary Antibody for IHC, IHC (p) - ABIN4310666 : Caruso, Herberth, Bartoli, Puppo, Dumonceaux, Zimmermann, Denadai, Lebossé, Roche, Geng, Magdinier, Attarian, Bernard, Maina, Levy, Helmbacher: Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. in PLoS genetics 2013 (PubMed)
    Show all 2 Pubmed References

More Antibodies against FAT Tumor Suppressor Homolog 1 (Drosophila) Interaction Partners

Human FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) interaction partners

  1. Study showed that FAT1 exhibits a high frequency of mutations and a downregulated expression in esophageal squamous cell carcinoma (ESCC) leading to cell migration and invasion by affecting the cellular mechanical properties of ESCC cells.

  2. FAT1 has a novel regulatory effect on EMT (show ITK Antibodies)/stemness markers both via or independent of HIF-1alpha (show HIF1A Antibodies). The functional relevance of this study was corroborated by significant reduction in the number of soft-agar colonies formed in hypoxic-siFAT1 treated U87MG cells.

  3. FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative head and neck squamous cell carcinoma; FAT1 mutation was significantly associated with better overall survival

  4. Disruption of MAPK/ERK (show MAPK1 Antibodies) pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas.

  5. Loss of function mutations in FAT1 and CASP8 (show CASP8 Antibodies) prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.

  6. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1 (show GPS1 Antibodies)) and FAT1

  7. FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC (show CALR Antibodies).

  8. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1 (show SH3RF1 Antibodies)) protein interact with FAT1 protein.

  9. At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha (show HIF1A Antibodies) was due to compromised EGFR (show EGFR Antibodies)-Akt (show AKT1 Antibodies) signaling as well as increased VHL (show VHL Antibodies)-dependent proteasomal degradation of HIF1alpha (show HIF1A Antibodies).

  10. Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt (show WNT2 Antibodies) signaling pathway to exert its antitumor effect

Mouse (Murine) FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) interaction partners

  1. The protection of fat-1 mice from UVB-induced skin inflammation was associated with decreased phosphorylation of STAT3 (show STAT3 Antibodies). Moreover, UVB-induced apoptosis was attenuated in fat-1 mouse skin.

  2. Balanced diet-fed Fat-1 mice are able to preserve in part the soleus muscle mass, absolute isotonic force and cross-sectional area of the soleus muscle in a disuse condition.

  3. studies suggest that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury. Given recent reports linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this Fat1 function may have importance in other settings of altered cell growth and metabolism

  4. Fat1 deletion in podocytes induces abnormal glomerular filtration barrier development leading to podocyte foot process effacement. Fat1 knockdown in renal tubular cells reduces migration, decreases active RAC1 (show RAC1 Antibodies)/CDC42 (show CDC42 Antibodies) and induces defects in lumen formation.

  5. Fat1 interacts with Fat4 (show FAT4 Antibodies) to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.

  6. Fat-1 expression suppresses CD4+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin in bronchoalveolar lavage and lung tissues of mice.

  7. Endogenous synthesis of n-3 PUFA in the fat-1 mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.

  8. FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity

  9. Data find that Fat1 and Fat4 (show FAT4 Antibodies) cooperate during mouse development to control renal tubular elongation, cochlear extension, cranial neural tube formation and patterning of outer hair cells in the cochlea.

  10. results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development

Pig (Porcine) FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) interaction partners

  1. these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.

FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Antigen Profile

Protein Summary

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described.

Gene names and symbols associated with FAT1

  • FAT atypical cadherin 1 (FAT1) antibody
  • FAT atypical cadherin 1 (Fat1) antibody
  • FAT tumor suppressor homolog 1 (Drosophila) (FAT1) antibody
  • protocadherin Fat 1 (LOC100175143) antibody
  • FAT atypical cadherin 1 (fat1) antibody
  • 2310038E12Rik antibody
  • AU023433 antibody
  • CDHF7 antibody
  • CDHR8 antibody
  • FAT antibody
  • FAT1 antibody
  • Fath antibody
  • hFat1 antibody
  • ME5 antibody
  • mFat1 antibody

Protein level used designations for FAT1

FAT tumor suppressor 1 , FAT tumor suppressor homolog 1 , cadherin ME5 , cadherin family member 7 , cadherin-related family member 8 , cadherin-related tumor suppressor homolog , protein fat homolog , protocadherin Fat 1 , fat 1 cadherin , FAT tumor suppressor homolog 1 (Drosophila) , fat1-like , protocadherin Fat 1-like

GENE ID SPECIES
2195 Homo sapiens
14107 Mus musculus
395168 Gallus gallus
475621 Canis lupus familiaris
508251 Bos taurus
703034 Macaca mulatta
760178 Strongylocentrotus purpuratus
100050525 Equus caballus
100154043 Sus scrofa
100175143 Ciona intestinalis
100407761 Callithrix jacchus
100471195 Ailuropoda melanoleuca
100489070 Xenopus (Silurana) tropicalis
100549464 Meleagris gallopavo
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