FER Tyrosine Kinase (FER) ELISA Kits

Human FER Tyrosine Kinase (FER) interaction partners

1. Targeting of both FER and MET may be an effective strategy for therapeutic intervention in ovarian cancer.

2. The FER rs4957796 TT genotype remained a significant covariate for the 90-day mortality risk in the multivariate analysis (hazard ratio, 4.62; 95% CI, 1.58-13.50; p = 0.0050). In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients with severe ARDS due to pneumonia.

3. FER enhances IGF-1R expression, phosphorylation, and signaling to promote cooperative growth and adhesion signaling that may facilitate cancer progression.

4. FER overexpression improves survival through STAT activation enhancing innate immunity and accelerating bacterial clearance in the lung.

5. Data show that FER tyrosine kinase (Fer/FerT) activity was disrupted by E260, which selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation.

6. We propose a model for the regulation of Fer based on an intramolecular interaction and the curvature-dependent membrane binding mediated by its intrinsically disordered region.

7. Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice.

8. Fer serves as a crucial mediator and amplifier of Src-induced tumor progression.

9. FER encodes a cytosolic non-receptor tyrosine kinase that influences neutrophil chemotaxis and endothelial permeability.

10. Fer contributes to aberrant androgen receptor signaling via pSTAT3 cross-talk during castrate-resistant prostate cancer progression.

11. Detection of PJA2-FER fusion mRNA is correlated with poor postoperative survival periods in non-small cell lung cancer.

12. data show that Fer kinase is elevated in non-small cell lung cancer tumors and is important for cellular invasion and metastasis

13. FER kinase promotes breast cancer metastasis by regulating alpha6- and beta1-integrin-dependent cell adhesion and anoikis resistance.

14. Fer expression correlates with renal cell carcinoma cell proliferation both in vitro and in vivo, and with tumor progression and survival

15. Fer, a non-receptor-type tyrosine kinase, plays a critical role in synthesis of the laminin-binding glycans on alpha-DG.

16. Transcription of the ferT gene in CC cells was found to be driven by an intronic promoter residing in intron 10 of the fer gene and to be regulated by the Brother of the Regulator of Imprinted Sites (BORIS) transcription factor.

17. The A allele of SNP rs10447248 in the FER locus was nominally associated with lower MMW (P = 0.016) but was not associated with LMW (P > 0.05) adiponectin levels

18. Overexpression of FER from a cDNA confers quinacrine resistance to several different types of cancer cell lines.

19. tyrosine phosphorylation of RhoGDIalpha by Fer as a mechanism to regulate binding of RhoGDIalpha to Rac

20. FER plays a role in the invasion and metastasis of hepatocellular carcinoma cells.

Mouse (Murine) FER Tyrosine Kinase (FER) interaction partners

1. Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation.

2. levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells

3. directed mitochondrial accumulation of FerT endowed nonmalignant cells with tumor-forming ability

4. a critical role of Fer in PDGF-BB-induced STAT3 activation and cell transformation.

5. Fer is a novel inhibitory kinase for neutrophil chemotaxis toward end target chemoattractants through modulation of PI3K activity.

6. FER kinase plays a critical role in oocyte meiotic spindle microtubule dynamics and may have an additional function in GVBD.

7. NRP1 has a role in signaling Sema3A-evoked neuronal death through Fer in cortical neurons

8. Endotoxin-induced leukocyte adhesion and emigration are significantly elevated in Fer-mutant mice relative to wild-type mice and demonstrate an essential role for Fer kinase in regulating inflammation-induced leukocyte emigration.

9. association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer

10. Fer sustains the activation of ERK1/2 and increases the production of VEGF in hypoxic cells

11. FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics