FXYD Domain Containing Ion Transport Regulator 3 Proteins (FXYD3)

Human FXYD Domain Containing Ion Transport Regulator 3 (FXYD3) interaction partners

1. Scn1b and Fxyd1 expression was significantly downregulated in HSCR colon.

2. Suppression of FXYD3 in MCF-7.

3. Study demonstrated that the expression of FXYD1, FXYD3 and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients

4. All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis.

5. ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration.

6. Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.

7. FXYD3 expression is related to several biological variables including ras, p53, legumain and PCNA, and may be involved in the development of the relatively early stages of colorectal cancers

8. Upregulation of FXYD3 is associated with glioma.

9. inactivation of FXYD3 through a gene mutation or unknown mechanism could be one cause of the atypical shapes of cancer cells and play a potential role in the progression of lung cancer.

10. molecular cloning, protein expression, sequencing and NMR structure determination

11. Results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas.

12. overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy

13. show that the helical regions and connecting segments of FXYD1, FXYD3, and FXYD4 determined in micelles by NMR spectroscopy coincide with the positions of intron-exon junctions in the genes

14. analysis of two human FXYD3 isoforms that are differentially expressed in differentiated and non-differentiated cells with different functional properties

15. FXYD3 interacts with Na(+)-K(+)-Exchanging ATPase in colorectal neoplasms.

16. structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid

17. FXYD3 silencing prevents proper regulation of Na,K-ATPase, which leads to perturbation of cellular Na+ and K+ homeostasis and changes in the expression of Na,K-ATPase isozymes, whose functional properties are incompatible with cell differentiation.

18. FXYD3a protein is highly expressed in breast cancers, and responsible for cancer cell proliferation.

Mouse (Murine) FXYD Domain Containing Ion Transport Regulator 3 (FXYD3) interaction partners

1. Because gluco-incretin secretion depends on feeding the epigenetic regulation of Fxyd3 expression may link nutrition in early life to establishment of adult beta-cell glucose competence.

2. Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression

3. regulator of Na,K-ATPase