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FXYD3 belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids.
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Suppression of FXYD3 in MCF-7.
Study demonstrated that the expression of FXYD1 (show FXYD1 Proteins), FXYD3 and FXYD5 (show FXYD5 Proteins) is elevated in the lungs of Acute respiratory distress syndrome patients
All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (show S100A11 Proteins) (p = 0.0071), and GSTM3 (show GSTM3 Proteins) (p = 0.0173) in colon cancer lymphatic metastasis.
ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration.
Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
FXYD3 expression is related to several biological variables including ras, p53 (show TP53 Proteins), legumain (show LGMN Proteins) and PCNA (show PCNA Proteins), and may be involved in the development of the relatively early stages of colorectal cancers
Upregulation of FXYD3 is associated with glioma.
inactivation of FXYD3 through a gene mutation or unknown mechanism could be one cause of the atypical shapes of cancer cells and play a potential role in the progression of lung cancer.
Results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas.
overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy
Because gluco-incretin secretion depends on feeding the epigenetic regulation of Fxyd3 expression may link nutrition in early life to establishment of adult beta-cell glucose competence.
Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression
regulator of Na,K-ATPase (show ATP1A1 Proteins)
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
FXYD domain containing ion transport regulator 3
, FXYD domain-containing ion transport regulator 3
, chloride conductance inducer protein Mat-8
, mammary tumor 8 kDa protein
, phospholemman-like protein