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FXYD4 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids.
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CHIF (show DBF4 Antibodies) can act as tissue-specific modulators of Na-K-ATPase (show ATP1A1 Antibodies)
data are consistent with an effect of CHIF on the Na(+)-K(+)-ATPase (show ATP1A1 Antibodies) specific to the outer and inner medullary duct
Corticosteroid hormone induced factor (CHIF) is a small epithelial-specific protein regulated by aldosterone and K+ intake.
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.
FXYD domain-containing ion transport regulator 4
, channel-inducing factor
, channel inducing factor
, corticosteroid-induced protein