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FYCO1 encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. Additionally we are shipping FYCO1 Kits (4) and FYCO1 Proteins (4) and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal FYCO1 Primary Antibody for IP, WB - ABIN4312910
Zhao, Huang, Han, Wang, Cheng, Zhao, Chen, Chen, Cheng, Xiao, Zheng: Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. in The Journal of biological chemistry 2012
Show all 2 Pubmed References
Human Polyclonal FYCO1 Primary Antibody for IHC, IHC (p) - ABIN4312911
Raiborg, Wenzel, Pedersen, Olsvik, Schink, Schultz, Vietri, Nisi, Bucci, Brech, Johansen, Stenmark: Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. in Nature 2015
Human Polyclonal FYCO1 Primary Antibody for ELISA, WB - ABIN566354
Pankiv, Alemu, Brech, Bruun, Lamark, Overvatn, Bjørkøy, Johansen: FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. in The Journal of cell biology 2010
FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation
FYCO1 and MAP1LC3A interact through a novel binding mode that involves Atg8-family proteins
Rare missense variants in FYCO1 are overrepresented in sporadic inclusion body myositis patients.
FYCO1 requires a functional LC3A/B-preferring LC3-interacting Region (LIR) motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected
FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population.
We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport.
Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors.
Ribonucleoprotein granule homeostasis is regulated by FYCO1-mediated autophagy.
The crystal structure of mouse LC3B in complex with the FYCO1 LC3-interacting region (LIR) reveals the importance of the flanking region of the LIR motif.
FYVE and coiled-coil domain containing 1 (FYCO1), a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 to Dectin-1 phagosomes.
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
FYVE and coiled-coil domain-containing protein 1
, FYVE and coiled-coil domain containing 1
, FYVE and coiled-coil domain-containing protein 1-like
, RUN and FYVE domain containing 3
, zinc finger FYVE domain-containing protein 7
, maternal embryonic message 2