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When transfected into cell lines in which it is not expressed, suppresses cell growth.
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Cow (Bovine) Polyclonal FAM107A Primary Antibody for WB - ABIN2775365
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 (show COMMD1 Antibodies) that is involved in NF-kappaB (show NFKB1 Antibodies) degradation and cell cycle suppression in neuroblastoma (show ARHGEF16 Antibodies) cells.
Importance of FAM107A in lung carcinogenesis, although other than promoter hypermethylation mechanism of the gene decreased expression.
Results found that DRR expression leads to elevated AKT (show AKT1 Antibodies) activation by recruiting AKT (show AKT1 Antibodies) to focal adhesios in a manner dependent on SRC (show SRC Antibodies)-family kinases (SFKs) and cell adhesion.
DRR1 protein is expressed in normal cells, particularly in the nervous system during embryogenesis, is involved in neuronal cell survival, and is downregulated during neuroblastoma (show ARHGEF16 Antibodies) carcinogenesis.
Expression of the down-regulated in renal cell carcinoma (show MOK Antibodies) gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2 "chr3+" tumours.
TU3A is epigenetically inactivated in human cancer
Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate (show GRIN1 Antibodies) release, and altered cognitive performance.
When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.
uncharacterized protein LOC494764
, down-regulated in renal cell carcinoma 1
, family with sequence similarity 107 member A transcript
, protein FAM107A
, downregulated in renal cell carcinoma