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When transfected into cell lines in which it is not expressed, suppresses cell growth.
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This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 (show COMMD1 Proteins) that is involved in NF-kappaB (show NFKB1 Proteins) degradation and cell cycle suppression in neuroblastoma (show ARHGEF16 Proteins) cells.
Importance of FAM107A in lung carcinogenesis, although other than promoter hypermethylation mechanism of the gene decreased expression.
Results found that DRR expression leads to elevated AKT (show AKT1 Proteins) activation by recruiting AKT (show AKT1 Proteins) to focal adhesios in a manner dependent on SRC (show SRC Proteins)-family kinases (SFKs) and cell adhesion.
DRR1 protein is expressed in normal cells, particularly in the nervous system during embryogenesis, is involved in neuronal cell survival, and is downregulated during neuroblastoma (show ARHGEF16 Proteins) carcinogenesis.
Expression of the down-regulated in renal cell carcinoma (show MOK Proteins) gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2 "chr3+" tumours.
TU3A is epigenetically inactivated in human cancer
Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate (show GRIN1 Proteins) release, and altered cognitive performance.
When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.
uncharacterized protein LOC494764
, down-regulated in renal cell carcinoma 1
, family with sequence similarity 107 member A transcript
, protein FAM107A
, downregulated in renal cell carcinoma