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Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. Additionally we are shipping Family with Sequence Similarity 175, Member B Proteins (5) and many more products for this protein.
Showing 9 out of 14 products:
Human Polyclonal FAM175B Primary Antibody for IP, WB - ABIN253066
Brockmeyer, Paster, Pepper, Tan, Trudgian, McGowan, Fu, Gascoigne, Acuto, Salek: T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. in The Journal of biological chemistry 2011
Cow (Bovine) Polyclonal FAM175B Primary Antibody for WB - ABIN2786186
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
In late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex.
KIAA0157 allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.
ABRO1 is a novel p53 regulator that plays an important role in tumor suppression and the DNA damage response
Study identified Abro1 as a specific interactor of THAP5, a zinc finger transcription factor that is involved in G2/M control and apoptosis.
Abro1 deficiency results in increased chromosome instability, and Abro1-null mice are tumor-prone.
Abraxas deficiency causes defective DNA repair, genetic instability, decreased survival and increased tumor incidence.
Data shows that the expression of Abro1 protein substantially increased (at least three-fold) in the hearts of mice that underwent MI/R compared to sham operated controls.
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex (By similarity).
BRISC complex subunit Abro1
, Abraxas brother protein 1
, Protein FAM175B
, family with sequence similarity 175, member B
, abraxas brother 1
, abraxas brother protein 1