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FAM189B is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. Additionally we are shipping Family with Sequence Similarity 189, Member B Proteins (3) and many more products for this protein.
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our findings suggest that the cytoplasmic protein COTE1 contributes to hepatocellular carcinoma tumorigenesis by regulating cell proliferation through the modulation of WWOX signaling
Overexpression of COTE1 promotes cellular invasion of hepatocellular carcinoma.
This gene is located near the gene for the lysosomal enzyme glucosylceramidase\; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants.