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Involved in cellular calcium homeostasis regulation (By similarity). Additionally we are shipping Family with Sequence Similarity 82, Member A2 Proteins (2) and and many more products for this protein.
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Human Polyclonal FAM82A2 Primary Antibody for ICC, IF - ABIN4348585
De Vos, Mórotz, Stoica, Tudor, Lau, Ackerley, Warley, Shaw, Miller: VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. in Human molecular genetics 2012
Study shows that the VAPB (show VAPB Antibodies)-PTPIP51 tethers regulate autophagy and demonstrates that overexpression of VAPB (show VAPB Antibodies) or PTPIP51 to tighten endoplasmic reticulum-mitochondria contacts impairs, whereas small interfering RNA-mediated loss of VAPB (show VAPB Antibodies) or PTPIP51 to loosen contacts stimulates, autophagosome formation.
the latest findings concerning PTPIP51 protein function, regulation and protein complex formation with regard to the involved signaling pathways and subcellular compartments (review)
High PTPIP51 expression is associated with glioblastoma.
PTPIP51 is regulated by its phosphorylation status combined with a thereby induced subcellular redistribution.
The presented data confirms a tyrosine phosphorylation-dependent interaction of PTPIP51 with 14-3-3beta and Raf-1 (show RAF1 Antibodies) in vivo and a tyrosine-dependent interaction profile with DAGKalpha and PKA.
In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B (show PTPN1 Antibodies).
PTPIP51 is phosphorylated by Lyn (show LYN Antibodies) and c-Src (show SRC Antibodies) kinases lacking dephosphorylation by PTP1B (show PTPN1 Antibodies) in acute myeloid leukemia (show BCL11A Antibodies).
PTPIP51 expression was restricted to myeloid precursor cells undergoing differentiation. In blood cells therefore, PTPIP51 expression is restricted to differentiating and mature neutrophil granulocytes.
PTPIP51 might be involved in the regulation of cellular processes associated with differentiation, movement, or cytoskeletal organization
PTPIP51 is a mitochondrial protein (show COX6B2 Antibodies) with apoptosis-inducing function and that the N-terminal TM domain is required for both the correct targeting of the protein to mitochondria and its apoptotic functions.
Protein interaction profile of PTPIP51 suggests a role in the memory formation in the hippocampus and cerebellum.
PTPIP51(protein tyrosine phosphatase interacting protein 51) might serve as a linking protein in adipocyte metabolism by connecting the insulin receptor (show INSR Antibodies)-triggered lipogenesis with the protein kinase A-dependent lipolysis.
The interaction of PTPIP51 with 14-3-3beta, especially in trained individuals, hints to an involvement of PTPIP51 in the downstream regulation of insulin (show INS Antibodies) action.
The data presented here suggest a role of PTPIP51 in neuronal homeostasis, axonal growth, and transport.
The PTPIP51 was integrated in signaling cascades regulating differentiation and apoptosis during eye development.
Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).
family with sequence similarity 82, member A2
, family with sequence similarity 82, member C
, regulator of microtubule dynamics protein 3
, Protein FAM82C
, TCPTP-interacting protein 51
, cerebral protein 10
, microtubule-associated protein
, protein tyrosine phosphatase-interacting protein 51
, tyrosine phosphatase interacting protein 51