Fanconi Anemia, Complementation Group L (FANCL) ELISA Kits

Human Fanconi Anemia, Complementation Group L (FANCL) interaction partners

1. A novel homozygous mutation c.822_823insCTTTCAGG (p.Asp275LeufsX13) in the FANCL gene identified in a Chinese patient with Fanconi anemia (show PALB2 ELISA Kits).

2. Using small interfering RNA (siRNA), knockdown of FANCF, FANCL, or FANCD2 inhibited function of the FA/BRCA pathway in A549, A549/DDP and SK-MES-1 cells, and potentiated sensitivity of the three cells to cisplatin.

3. Loss-of-Function FANCL Mutations Associate with Severe Fanconi Anemia (show PALB2 ELISA Kits) Overlapping the VACTERL Association

4. a signal transduction pathway involved in self-renewal and survival of hematopoietic stem cells also functions to stabilize FANCL and suggesting that FANCL participates directly in support of stem cell function.

5. Suppression of FANCL expression in normal CD34(+) stem and (show CTNNB1 ELISA Kits)progenitor cells results in fewer beta-catenin active cells and inhibits expansion of multilineage progenitors.

6. FA DNA repair genes, FANCD2, FANCL, and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer

7. genetic diversity in FANCA (show FANCA ELISA Kits), FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population.

8. FANCL is associated with acute lung injury in mice

9. expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor

10. data suggest that PHF9 has a crucial role in the Fanconi anemia (show PALB2 ELISA Kits) pathway as the likely catalytic subunit required for monoubiquitination of FANCD2 (show FANCD2 ELISA Kits)

Mouse (Murine) Fanconi Anemia, Complementation Group L (FANCL) interaction partners

1. The authors report the structure of the human FANCL central domain and show that the RING domain is necessary and sufficient for E2 binding.

2. Using HeLa cells and lymphoblasts from Fanconi anemia (show PALB2 ELISA Kits) patients, the authors characterize PHF9 (FANCL) as a ubiquitin ligase and show it is essential for FANCD2 (show FANCD2 ELISA Kits) monoubiquitination. The authors state that PHF9 is the human homolog of mouse Pog (Fancl).

3. FANCL increases the activity and expression of beta-catenin (show CTNNB1 ELISA Kits), a key pluripotency factor in hematopoietic stem cells.

4. UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6.

5. Fancl is associated with acute lung injury

6. expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor

7. Deletion of Pog causes germ cell deficiency, but is also accompanied by reduced embryonic body weight and sometimes lethality.

8. GGN1 and GGN3, interacted with POG, regulated the localization of POG, and played a role in spermatogenesis.

9. unlike in POG-deficient females, the germ cells in POG-deficient males eventually populate the seminiferous tubules at 9 wk, and fertility can be achieved by 12 wk.