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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCM Kits (4) and and many more products for this protein.
Showing 10 out of 83 products:
Human Monoclonal FANCM Primary Antibody for ICC, IF - ABIN4310526
Fouquet, Pawlikowska, Caburet, Guigon, Mäkinen, Tanner, Hietala, Urbanska, Bellutti, Legois, Bessieres, Gougeon, Benachi, Livera, Rosselli, Veitia, Misrahi: A homozygousFANCMmutation underlies a familial case of non-syndromic primary ovarian insufficiency. in eLife 1970
Human Polyclonal FANCM Primary Antibody for ELISA - ABIN4271349
Barroso, Pita, Arias, Menendez, Zamora, Blanco, Benitez, Ribas: The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. in Breast cancer research and treatment 2009
Loss-of-function mutations in FANCM cause a cancer predisposition syndrome clinically distinct from bona fide FA. Care should be taken with chemotherapy and radiation treatments in these patients due to expected acute toxicity.
Our data indicate that biallelic FANCM mutations do not cause classical FA, providing proof that FANCM is not a canonical FA gene. FANCM is a breast cancer-predisposing gene. Mutation testing of FANCM might be considered for individuals with the above-described clinical features.
Two FANCM truncating mutations, the c.1432C>T (p.Arg478Ter) and c.1972C>T (p.Arg658Ter), were identified in two Male Breast Cancer cases (0.7%). When specifically considering cases at increased genetic risk for BC, FANCM mutation frequency raises up to 1%. Rare FANCM truncating mutations, other than c.5101C>T and c.5791C>T, may have a role in MBC (show DOCK2 Antibodies) susceptibility.
Mutation in FANCM gene is associated with non-syndromic primary ovarian insufficiency.
These results support the role of FANCM as a breast cancer susceptibility gene, particularly for triple-negative breast cancer.
FANCM is actively recruited to the alternative lengthening of telomeres that are experiencing replication stress.
we demonstrated that FANCM is a direct target of miR146a
This case-control study included 2047 BRCA1 and BRCA2 (show BRCA2 Antibodies)-negative familial breast cancer cases and 2187 controls and revealed an association of FANCM mutations with breast cancer. More pronounced associations were identified for early-onset (before age 51 years) breast cancer and triple-negative breast cancer.
FANCM c.5101C > T nonsense mutation carriers have a reduced breast cancer survival but postoperative radiotherapy may diminish this survival disadvantage.
we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer.
Fancm(Delta2/Delta2) mice also showed unique features atypical for Fanconi anemia (show PALB2 Antibodies) mice, including underrepresentation of female Fancm(Delta2/Delta2) mice and decreased overall and tumor-free survival.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M.
Fanconi anemia complementation group M
, fanconi anemia complementation group M
, ATP-dependent RNA helicase FANCM
, Fanconi anemia group M protein
, fanconi anemia-associated polypeptide of 250 kDa
, protein Hef ortholog
, Fanconi anemia group M protein homolog