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Functions as a receptor for the Fc fragment of IgA and IgM. Additionally we are shipping FCAMR Proteins (7) and FCAMR Kits (2) and many more products for this protein.
Showing 8 out of 9 products:
A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.
A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels.
ADAM10 and ADAM17 are involved in the shedding of FcalphaR
LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages
These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR.
Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans.
These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues
the cytoplasmic portion of human Fcalpha/microR is required in the internalization.
Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells.
Serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on follicular dendritic cells in the F1 mice.
These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production.
Data suggest that Fcalpha/muR does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.
A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.
Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]
expressed in oligodendrocytes, their precursor cells, and myelin
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Fc receptor, IgA, IgM, high affinity
, Fc alpha/mu receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor-like
, immunity related factor
, receptor for Fc fragment of IgA and IgM
, Fc IgA/IgM receptor
, Fca/m receptor
, fc alpha/mu receptor