anti-Fibrinogen alpha Chain (FGA) Antibodies

The protein encoded by FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Additionally we are shipping Fibrinogen alpha Chain Kits (63) and Fibrinogen alpha Chain Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FGA 2243 P02671
FGA 14161  
FGA 361969  
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Top anti-Fibrinogen alpha Chain Antibodies at

Showing 10 out of 132 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-FGA Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Hela cell lysate Host:  Rabbit  Target Name:  FGA  Sample Tissue:  Human NCI-H226  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of FGA expression in rat skeletal muscle extract ( Lane 1) and HEPG2 whole cell lysates ( Lane 2). FGA at 95KD was detected using rabbit anti- FGA Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-FGA Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate Rabbit Anti-FGA Antibody  Paraffin Embedded Tissue: Human Skin Cellular Data: Squamous epithelial cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Liver Tissue; Lane2: Human Blood Cells. 100 μg 15 to 18 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of FGA Antibody (N-term) (ABIN390830) in Jurkat cell line lysates (35 µg/lane). FGA (arrow) was detected using the purified polyclonal antibody. FGA Antibody (N-term) (ABIN390830) IHC analysis in formalin fixed and paraffin embedded human breast carcinoma tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL 10 to 11 Days
Human Rabbit Un-conjugated EIA, WB   0.4 mL 4 to 8 Days
Cow Rabbit Un-conjugated IHC, IHC (p), WB Anti-Fibrinogen Alpha / FGA antibody IHC staining of human colon, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugat ... 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of FGA using HeLa whole  lysates. ABIN6278027 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days

Top referenced anti-Fibrinogen alpha Chain Antibodies

  1. Human Polyclonal FGA Primary Antibody for WB - ABIN2776978 : Jood, Danielson, Ladenvall, Blomstrand, Jern: Fibrinogen gene variation and ischemic stroke. in Journal of thrombosis and haemostasis : JTH 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FGA Primary Antibody for IF (p), IHC (p) - ABIN873232 : Imamura, Yamada, Tsuboi, Nakane, Tsukasaki, Komatsuzaki, Jin: Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain. in Molecules (Basel, Switzerland) 2016 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal FGA Primary Antibody for IHC, WB - ABIN630126 : Matsumoto, Matsuura, Aoki, Maehashi, Iwamoto, Ohkawa, Yoshida, Yanaga, Takada: An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. in Hepatology research : the official journal of the Japan Society of Hepatology 2016 (PubMed)

More Antibodies against Fibrinogen alpha Chain Interaction Partners

Human Fibrinogen alpha Chain (FGA) interaction partners

  1. the presence of human serum albumin (HSA) or immunoglobulin G (IgG), which are both protected from intracellular degradation by the interaction with the neonatal Fc receptor (FcRn), results in a decreased amount of internalized fibrinogen.

  2. alphaIIbbeta3 binding to polymeric fibrin can be segregated into two binding regimes, one with weaker rupture forces of 30-60 pN and a second with stronger rupture forces >60 pN that peaked at 70-80 pN.

  3. The authors show here, using scanning electron microscopy and confocal microscopy, that platelet-poor-plasma from subjects with type 2 diabetes had a much greater propensity for hypercoagulability and for fibrin amyloidogenesis, and that these could both be reversed by LBP.

  4. ERp5 triggers fibrinogen dissociation from aIIbb3 integrin.

  5. Certain core genes, including COL12A1, glutathione Stransferase alpha3 (GSTA3), fibrinogen alpha chain (FGA) and fibrinogen gamma chain (FGG), were the first reported to be associated with Gastric Cancer. Survival analysis suggested that these four genes, COL12A1 (P=0.002), GSTA3 (P=3.4x106), FGA (P=0.00075) and FGG (P=1.4x105), were significant poor prognostic factors of gastric cancer.

  6. this study shows that hypofibrinogenaemia associated with novel Aalpha126Val-->Asp mutation in the fibrinogen coiled coil

  7. All the exons and exon-intron boundaries of fibrinogen genes (FGA, FGB and FGG) were analysed by direct DNA sequencing

  8. Taken together, an increased pretreatment plasma fibrinogen level was related to worse survival in digestive system tumors, indicating that it could be a useful prognostic marker in these types of tumors.

  9. The risk of early pregnancy loss was significantly higher in women with homozygous or heterozygous FGA: p.Thr331Ala polymorphism than in women with FGA: p.Thr331 (Odds ratio: 8.84, P < .05).

  10. Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.

  11. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.

  12. Fibrinogen A alpha arginine-glycine-aspartate sequence (residues 95-97) is essential for binding to its erythrocyte receptor.

  13. Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.

  14. High fibrinogen level is associated with Type-2 diabetes and diabetic vascular disease.

  15. The heterozygous AalphaArg16His and gammaAsp185Asn identified in the study probably underlie the dysfibrinogenemia in this pedigree, with the latter being identified for the first time.

  16. A brief history of some key events in the conversion of fibrinogen to fibrin has been reviewed. (Review)

  17. Preoperative fibrinogen levels appeared as an independent mortality risk factor in non-metastatic colorectal cancer patients with normal GPS scores

  18. evidence that VLITL confers amyloidogenic properties to Aalpha-chain frameshift variants, yielding a previously unknown molecular basis for the pathogenesis of Aalpha-chain amyloidosis

  19. We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury

  20. Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients.

Cow (Bovine) Fibrinogen alpha Chain (FGA) interaction partners

  1. two different approaches to tune the fibrillar structure and mechanical properties of fibrin hydrogels, are reported.

  2. Full-length bovine alphaC-domain, bAalpha374-568, and its human counterpart, hAalpha392-610, can form ordered oligomers in a similar manner.

  3. NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423.

  4. the complete NMR solution structure of the Aalpha406-483 alphaC-domain fragment, provide direct evidence for the intra- and intermolecular interactions between the alphaC-domains, and confirm that these interactions are thermodynamically driven.

Mouse (Murine) Fibrinogen alpha Chain (FGA) interaction partners

  1. cellular fibrin uptake was diminished by elimination of CCR2-expressing cells.

  2. Mice expressing a mutant form of fibrinogen cannot support fibrin formation exhibit compromised antimicrobial host defense.

  3. Data indicate RU-505 as an effective inhibitor of the beta-amyloid (Abeta)-fibrinogen interaction.

  4. These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of acute kidney injury.

  5. Data indicate that FXIIIa-targeted probe signals showed good overlap with immune-fluorescent fibrin staining images.

  6. Fbg deficiency was associated with enhanced hepatic expression of the transcription factor early growth response-1.

Fibrinogen alpha Chain (FGA) Antigen Profile

Protein Summary

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.

Gene names and symbols associated with FGA

  • fibrinogen alpha chain (FGA) antibody
  • fibrinogen alpha chain (Fga) antibody
  • fibrinogen alpha chain (LOC698244) antibody
  • Ac1873 antibody
  • ENSMUSG00000059807 antibody
  • Fba5e antibody
  • Fib antibody
  • Fib2 antibody

Protein level used designations for FGA

fibrinogen alpha chain , fibrinogen alpha chain-like , fibrinogen, A alpha polypeptide , fibrinogen A-alpha chain , fibrinogen, alpha polypeptide , carboxy-terminal region , fibrinogen A-alpha-chain , fibrinogen alpha subunit , fibrinogen alpha-E subunit , pre-fibrinogen alpha subunit

100461464 Pongo abelii
100469401 Ailuropoda melanoleuca
100607544 Nomascus leucogenys
2243 Homo sapiens
522039 Bos taurus
14161 Mus musculus
475473 Canis lupus familiaris
100514666 Sus scrofa
361969 Rattus norvegicus
396307 Gallus gallus
100720646 Cavia porcellus
100069763 Equus caballus
100353616 Oryctolagus cuniculus
698244 Macaca mulatta
101102090 Ovis aries
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