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The protein encoded by FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Additionally we are shipping Fibrinogen alpha Chain Kits (62) and Fibrinogen alpha Chain Proteins (15) and many more products for this protein.
Showing 10 out of 128 products:
Human Polyclonal FGA Primary Antibody for IF (p), IHC (p) - ABIN873232
Imamura, Yamada, Tsuboi, Nakane, Tsukasaki, Komatsuzaki, Jin: Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain. in Molecules (Basel, Switzerland) 2016
Show all 2 Pubmed References
Human Polyclonal FGA Primary Antibody for WB - ABIN2776978
Jood, Danielson, Ladenvall, Blomstrand, Jern: Fibrinogen gene variation and ischemic stroke. in Journal of thrombosis and haemostasis : JTH 2008
Show all 3 Pubmed References
Human Polyclonal FGA Primary Antibody for IHC, WB - ABIN630126
Matsumoto, Matsuura, Aoki, Maehashi, Iwamoto, Ohkawa, Yoshida, Yanaga, Takada: An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. in Hepatology research : the official journal of the Japan Society of Hepatology 2016
The risk of early pregnancy loss was significantly higher in women with homozygous or heterozygous FGA: p.Thr331Ala polymorphism than in women with FGA: p.Thr331 (Odds ratio: 8.84, P < .05).
Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.
CD47 (show CD47 Antibodies) expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 (show CD47 Antibodies) expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.
Fibrinogen A alpha arginine-glycine-aspartate sequence (residues 95-97) is essential for binding to its erythrocyte receptor (show CD2 Antibodies).
Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.
High fibrinogen level is associated with Type-2 diabetes and diabetic vascular disease.
A brief history of some key events in the conversion of fibrinogen to fibrin has been reviewed. (Review)
Preoperative fibrinogen levels appeared as an independent mortality risk factor in non-metastatic colorectal cancer patients with normal GPS (show NBEAL2 Antibodies) scores
We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury
Using a quantum chemical approach method, it has been established that mutations in MMP-10 (show MMP10 Antibodies) and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients.
NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423.
cellular fibrin uptake was diminished by elimination of CCR2-expressing cells.
Mice expressing a mutant form of fibrinogen cannot support fibrin formation exhibit compromised antimicrobial host defense.
Data indicate RU-505 as an effective inhibitor of the beta-amyloid (Abeta)-fibrinogen interaction.
Fbg deficiency was associated with enhanced hepatic expression of the transcription factor early growth response-1 (show EGR1 Antibodies).
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
fibrinogen alpha chain
, fibrinogen alpha chain-like
, fibrinogen, A alpha polypeptide
, fibrinogen A-alpha chain
, fibrinogen, alpha polypeptide
, carboxy-terminal region
, fibrinogen A-alpha-chain
, fibrinogen alpha subunit
, fibrinogen alpha-E subunit
, pre-fibrinogen alpha subunit