anti-Fibrinogen-Like 2 (FGL2) Antibodies

The protein encoded by FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. Additionally we are shipping Fibrinogen-Like 2 Kits (53) and Fibrinogen-Like 2 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FGL2 10875 Q14314
FGL2 84586  
FGL2 14190 P12804
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Top anti-Fibrinogen-Like 2 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FGL2 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Placenta WB Suggested Anti-FGL2  Antibody Titration: 0.2-1 µg/mL  Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to FGL2 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 0.5 ug/ml] FGL2 monoclonal antibody (M01), clone 6D9 Western Blot analysis of FGL2 expression in HeLa . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of FGL2 expression in HeLa (A), Jurkat (B), HuT78 (C), Molt4 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated FACS, WB FGL2 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FGL2 antibody detected the FGL2 protein (arrow). FGL2 Antibody (C-term)  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the FGL2 antibody detected the FGL2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IP, WB FGL2 MaxPab rabbit polyclonal antibody. Western Blot analysis of FGL2 expression in HeLa. Immunoprecipitation of FGL2 transfected lysate using anti-FGL2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with FGL2 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$363.46
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$551.83
Details
Mouse Rabbit Un-conjugated ICC, IHC, IHC (p), IP, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL Log in to see 11 to 14 Days
$390.50
Details
Rat Rabbit Un-conjugated ICC, IHC, IHC (p), IP, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL Log in to see 11 to 14 Days
$390.50
Details

Top referenced anti-Fibrinogen-Like 2 Antibodies

  1. Human Monoclonal FGL2 Primary Antibody for IHC (p), IP - ABIN564725 : OBrien, Morrison, Smith: Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor. in Biology of reproduction 2007 (PubMed)
    Show all 11 Pubmed References

  2. Cow (Bovine) Polyclonal FGL2 Primary Antibody for WB - ABIN2784837 : Pischke, Gustavsen, Orrem, Egge, Courivaud, Fontenelle, Despont, Bongoni, Rieben, Tønnessen, Nunn, Scott, Skulstad, Barratt-Due, Mollnes: Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. in Basic research in cardiology 2017 (PubMed)
    Show all 2 Pubmed References

  3. Rat (Rattus) Polyclonal FGL2 Primary Antibody for IF (p), IHC (p) - ABIN727785 : Yang, Fujikado, Kolodin, Benoist, Mathis: Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. in Science (New York, N.Y.) 2015 (PubMed)

More Antibodies against Fibrinogen-Like 2 Interaction Partners

Human Fibrinogen-Like 2 (FGL2) interaction partners

  1. FGL2 expression is a novel, independent, and an adverse prognostic factor of clinical outcomes in patients with clear cell renal cell carcinoma.

  2. Serum FGL2 is a promising biomarker for assessing the severity and prognosis in severe TBI

  3. FGL2 promotes tumor progression in the brain by suppressing CD103-expressing dendritic cell differentiation.

  4. serum levels of soluble FAS ligand (sFASL) and interferon gamma (IFN-gamma) were analyzed and correlated with sFGL2 levels in Hepatitis C Virus-Infected Patients and Hepatocellular Carcinoma Patients.

  5. Data suggest that fibrinogen-like protein 2 (hFGL2) gene silencing via miRNA may be an alternative strategy for the management of hepatocellular carcinoma (HCC).

  6. Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals

  7. Report increased expression of FGL-2 in peripheral blood mononuclear cells from mycosis fungoides patients.

  8. these results suggest that FGL-2 mediates angiogenesis and tumorigenesis not by thrombin-mediated mechanism but rather through FGF-2/ERK signaling pathway.

  9. Results show that FGL2 functions as a key immune-suppressive modulator and has potential as an immunotherapeutic target for treating glioblastoma multiforme (GBM).

  10. FGL-2 prothrombinase activity in PBMC of lymphoma patients is increased in active disease and normalizes during remission, thus being a potential marker for follow up of lymphoma patients.

  11. Studied fibrinogen-like protein 2 expression and its role in CRC metastasis and underlying molecular mechanisms; results suggest that FGL2 plays an important oncogenic role in CRC aggressiveness by inducing EMT.

  12. The selected peptide sequence NPG-12 may be a critical domain for hfgl2 prothrombinase activity.

  13. The proliferation index of CD8(+)T cells after blocking FGL2 was higher.

  14. immunomodulatory activity of FGL2 may be involved in the immunopathogenesis of inflammatory bowel disease

  15. Circulating fibrinogen-like protein 2 is increased in patients with systemic sclerosis.

  16. Serum fgl2 levels were increased among renal allograft recipients with acute rejection episodes to an extent dependent upon the pathological type and severity of the response.

  17. FGL2 contributes to hepatocellular carcinoma tumour growth and angiogenesis in a thrombin-dependent manner, and downregulation of its expression might be of therapeutic significance in HCC.

  18. HBV surface antigen-induced transcription of hfgl2 prothrombinase gene.

  19. FGL2 plays an important role in macrophage activation in the lungs of COPD patients through MAPK pathway modulation.

  20. FGL2 expression may be critical to the pathogenesis of renal allograft rejection; these data provide a rationale for targeting the fgl2 gene in an attempt to modulate allograft rejection.

Pig (Porcine) Fibrinogen-Like 2 (FGL2) interaction partners

  1. soluble FGL2 might be a potential renoprotective mediator involved in the renal self-repairing and remodeling.

  2. studies of pig-to-baboon kidney xenografts undergoing acute vascular rejection in vivo revealed induction of pfgl2 expression on graft vascular endothelial cells.

Mouse (Murine) Fibrinogen-Like 2 (FGL2) interaction partners

  1. our results presented herein point to Fgl2 as a novel protective molecule in the pathogenesis of IBD. We found that Fgl2 is critical for limiting DSS-induced colitis and subsequent CAC development through its effects on macrophage polarization

  2. These results indicated that FGL2 might be a promising target for attenuating the severity of Severe acute pancreatitis (SAP) and adenovirus-mediated artificial miRNAs targetting FGL2 represented a potential therapeutic approach for the treatment of SAP.

  3. The results of the present study indicated that, in the colitis model, FGL2 was associated with the immunopathogenesis of inflammatory bowel disease.

  4. FGL2-overexpressing regulatory T-cells have enhanced immunosuppressive activity and prevent colitis; FGL2-over-expressing effector T-cells are hypo-proliferative and do not induce colitis

  5. PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 after ICH, and that manipulation of PD-1 might be a promising therapeutical target in ICH.

  6. In vitro IL-33 treatment abrogated MHV-3 and IFN-gamma induced FGL2 expression in RAW264.7 and THP-1 cells.

  7. FGL2 appears as one of the key players in immune regulatory processes favoring metacestode survival by promoting Regulatory T-cell activity and IL-17A production that contributes to FGL2-regulation.

  8. TNF-alpha, and FGL2 form an integral network that contributes to coagulation and complement activation, and suggest that those are potential therapeutic targets in viral FH intervention.

  9. these data strongly suggest that Treg cells expressing FGL2 mediate rapamycin-induced tolerance. Furthermore, a gene biomarker panel that includes fgl2 can distinguish between rejecting and tolerant grafts.

  10. Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice.

  11. Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression.

  12. Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis.

  13. Cysteines at positions 94, 97, 184 and 187, found in the coiled-coil domain were shown to be crucial for FGL2 oligomerization.

  14. FGL2 binding to the FcgammaRIIB receptor expressed on sinusoidal endothelial cells (SECs) is a critical event in the initiation of the hepatic reperfusion injury cascade through induction of SEC and hepatocyte death.

  15. The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis.

  16. Fgl2 cleaves prothrombin to thrombin consistent with serine protease activity and requires calcium, phospholipids, and factor Va for its full activity.

  17. While membrane-bound Fgl2 acts as a prothrombinase, soluble Fgl2 is an immunomodulatory protein that has the ability to modulate T cell responses and to alter dendritic cell (DC) maturation to favor production of tolerogenic DC.

  18. fgl2 expression in endothelial cells is controlled by Ets-1 and Oct-1, and requires Sp1 and Sp3

  19. Fgl2 is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction.

  20. Fgl2-deficient and control mice produce similar levels of fibrin, a product of the coagulation cascade, during T. gondii infection and allograft rejection.

Fibrinogen-Like 2 (FGL2) Antigen Profile

Protein Summary

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.

Gene names and symbols associated with FGL2

  • fibrinogen like 2 (FGL2) antibody
  • fibrinogen like 2 L homeolog (fgl2.L) antibody
  • fibrinogen-like 2a (fgl2a) antibody
  • fibrinogen-like 2 (Fgl2) antibody
  • fibrinogen-like protein 2 (Fgl2) antibody
  • AI385601 antibody
  • FGL2 antibody
  • fibroleukin antibody
  • musfiblp antibody
  • pT49 antibody
  • si:ch211-276e22.3 antibody
  • T49 antibody
  • wu:fj83c10 antibody
  • zgc:136619 antibody

Protein level used designations for FGL2

fibrinogen-like 2 , fibroleukin , fibroleukin-like , fibrinogen-like protein 2 , associated with MHV-3 induced prothrombinase activity , cytotoxic T-lymphocyte-specific protein , prothrombinase

GENE ID SPECIES
475902 Canis lupus familiaris
495355 Xenopus laevis
565637 Danio rerio
694856 Macaca mulatta
768821 Gallus gallus
100228349 Taeniopygia guttata
100351573 Oryctolagus cuniculus
100393441 Callithrix jacchus
100439476 Pongo abelii
100608696 Pan troglodytes
100619845 Monodelphis domestica
10875 Homo sapiens
84586 Rattus norvegicus
448808 Sus scrofa
511711 Bos taurus
14190 Mus musculus
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