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Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.. Additionally we are shipping FGF15 Kits (21) and FGF15 Proteins (4) and many more products for this protein.
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Tumorigenicity was assessed in three mouse models (db/db (show LEPR Antibodies), diet-induced obese, and multi-drug resistance 2 [Mdr2 (show ABCB4 Antibodies)]-deficient) following continuous exposure to FGF19 (show FGF19 Antibodies) or FGF15 via adeno (show ADORA2A Antibodies)-associated viral-mediated gene delivery.
These data identify hypothalamic Fgf15 as a regulator of glucagon (show GCG Antibodies) secretion.
Fgf15 is the sonic hedgehog (show SHH Antibodies) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Antibodies) target genes Fgf15 and Shp (show LAMC1 Antibodies) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Antibodies) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
This study demonstrates that the FGF19 (show FGF19 Antibodies)-SHP (show LAMC1 Antibodies)-LSD1 (show KDM1A Antibodies) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 (show SREBF2 Antibodies) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).
Protective effects of farnesoid X receptor (show xpr1 Antibodies) on hepatic lipid accumulation are mediated by hepatic FXR (show NR1H4 Antibodies) and are independent of intestinal FGF15 signaling.
Intestinal PPARalpha (show PPARA Antibodies)-UDP- Glucuronyltransferases and downstream FXR (show NR1H4 Antibodies)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (show POR Antibodies) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (show POR Antibodies) function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
, fibroblast growth factor 15