anti-Fibroblast Growth Factor 15 (FGF15) Antibodies

Mouse (Murine) Fibroblast Growth Factor 15 (FGF15) interaction partners

1. FRS2alpha (show FRS2 Antibodies)-mediated pathways are essential for the FGF15/FGF19-FGFR4 (show FGFR4 Antibodies) signaling axis to control bile acid homeostasis.

2. Together, our results show that SuFu (show SUFUH Antibodies) promotes cerebellar radial precursor differentiation to neurons. SuFu (show SUFUH Antibodies) function is mediated in part by GLI3R and down-regulation of Fgf15 expression.

3. Results show a reciprocal regulation of adiponectin and FGF19 (show FGF19 Antibodies) gene expression in mice.

4. Tumorigenicity was assessed in three mouse models (db/db (show LEPR Antibodies), diet-induced obese, and multi-drug resistance 2 [Mdr2 (show ABCB4 Antibodies)]-deficient) following continuous exposure to FGF19 (show FGF19 Antibodies) or FGF15 via adeno (show ADORA2A Antibodies)-associated viral-mediated gene delivery.

5. These data identify hypothalamic Fgf15 as a regulator of glucagon (show GCG Antibodies) secretion.

6. Fgf15 is the sonic hedgehog (show SHH Antibodies) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.

7. human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Antibodies) target genes Fgf15 and Shp (show LAMC1 Antibodies) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Antibodies) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota

8. This study demonstrates that the FGF19 (show FGF19 Antibodies)-SHP (show LAMC1 Antibodies)-LSD1 (show KDM1A Antibodies) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.

9. The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.

10. This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 (show SREBF2 Antibodies) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).