Fibroblast Growth Factor 15 Proteins (FGF15)

Mouse (Murine) Fibroblast Growth Factor 15 (FGF15) interaction partners

1. ileal FGF15/19 to hepatic FGFR4 (show FGFR4 Proteins) axis is activated and promotes liver regeneration (LR) after partial hepatectomy (PH) in mice, supporting the potential of ileal FGF15/19 to hepatic FGFR4 (show FGFR4 Proteins) axis-targeted therapy to enhance LR after PH

2. FRS2alpha (show FRS2 Proteins)-mediated pathways are essential for the FGF15/FGF19-FGFR4 (show FGFR4 Proteins) signaling axis to control bile acid homeostasis.

3. Together, our results show that SuFu (show SUFUH Proteins) promotes cerebellar radial precursor differentiation to neurons. SuFu (show SUFUH Proteins) function is mediated in part by GLI3R and down-regulation of Fgf15 expression.

4. Results show a reciprocal regulation of adiponectin and FGF19 (show FGF19 Proteins) gene expression in mice.

5. Tumorigenicity was assessed in three mouse models (db/db (show LEPR Proteins), diet-induced obese, and multi-drug resistance 2 [Mdr2 (show ABCB4 Proteins)]-deficient) following continuous exposure to FGF19 (show FGF19 Proteins) or FGF15 via adeno (show ADORA2A Proteins)-associated viral-mediated gene delivery.

6. These data identify hypothalamic Fgf15 as a regulator of glucagon (show GCG Proteins) secretion.

7. Fgf15 is the sonic hedgehog (show SHH Proteins) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.

8. human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Proteins) target genes Fgf15 and Shp (show LAMC1 Proteins) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Proteins) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota

9. This study demonstrates that the FGF19 (show FGF19 Proteins)-SHP (show LAMC1 Proteins)-LSD1 (show KDM1A Proteins) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.

10. The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.