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FGFBP1 encodes a secreted fibroblast growth factor carrier protein. Additionally we are shipping FGFBP1 Antibodies (60) and FGFBP1 Kits (43) and many more products for this protein.
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These findings indicate that the miR (show MLXIP Proteins)-146a-CREB3L1 (show CREB3L1 Proteins)-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells.
Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension.
Up-regulated Sox12 (show SOX12 Proteins) induced by FoxQ1 (show FOXQ1 Proteins) promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 (show TWIST1 Proteins) and FGFBP1 expression.
overexpression of FGFBP1 or loss of WISP-2 (show WISP2 Proteins) expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.
FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations.
Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk.
Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair.
the FGF interaction domain is contained in the C terminus of FGF-BP1
FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review]
The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 (show FGF2 Proteins) in renal capillaries can be modulated in children with HIV-HUS (show CFH Proteins) and other renal disease.
FGFBP1 expression decreases in skeletal muscles during aging and before neuromuscular junctions degeneration in SOD1 (show SOD1 Proteins)(G93A) mice
From the locally confined, time-dependent, and apparently tightly regulated FGF-BP expression, it is proposed that FGF-BP may play an important role in embryonic development.
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.
fibroblast growth factor binding protein 1
, fibroblast growth factor-binding protein 1
, fibroblast growth factor-binding protein 1-like
, 17 kDa HBGF-binding protein
, 17 kDa heparin-binding growth factor-binding protein
, FGF-binding protein 1
, heparin-binding growth factor binding protein
, growth factor binding protein-1
, growth factor-binding protein 1