Fibronectin Leucine Rich Transmembrane Protein 2 Proteins (FLRT2)

Human Fibronectin Leucine Rich Transmembrane Protein 2 (FLRT2) interaction partners

1. Taken together, these results provide insights into the role of FLRT2 as a novel tumor suppressor in the breast, which is inactivated by hypermethylation during tumor development.

2. OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci

3. The membrane protein, FLRT2, was identified as a novel autoantigen in systemic lupus erythematosus patients.

4. PCMC expression of ADAM29, FLRT2, and SLC18A3 could be assessed as part of a routine screen to help identify individuals at risk of severe Obstructive sleep apnea in Asian populations

Mouse (Murine) Fibronectin Leucine Rich Transmembrane Protein 2 (FLRT2) interaction partners

1. fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.

2. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.

3. FLRT2 may exist in both membrane-bound and shed forms which interact with fibronectin in the ATDC5 chondroprogenitor cells.

4. findings provide evidence for a role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis

5. mouse embryos lacking Flrt2 expression arrest at mid-gestation owing to cardiac insufficiency

6. Flrt2 was highly expressed initially in the cranial neural crest cells

7. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome in embryo