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FLRT3 encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. Additionally we are shipping FLRT3 Antibodies (20) and FLRT3 Kits (8) and many more products for this protein.
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The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.
XFLRT3 signalling results in phosphorylation of ERK (show MAPK1 Proteins) and is blocked by MAPK phosphatase 1 (show DUSP1 Proteins); results indicatethat XFLRT3 is a transmembrane modulator of FGF-MAP kinase (show MAPK1 Proteins) signalling
The results suggest that FLRT3, Unc5B (show UNC5B Proteins) and Rnd1 (show RND1 Proteins) proteins interact to modulate cell adhesion in early Xenopus development.
Mice with deletions of FLRT1 (show FLRT1 Proteins) and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
FLRT3 is a modulator of Netrin-1 (show NTN1 Proteins) response in axons.FLRT3 is a Robo1 (show ROBO1 Proteins) coreceptor.FLRT3 is a Robo1 (show ROBO1 Proteins)-interacting protein that determines Netrin-1 (show NTN1 Proteins) attraction in developing axons.
Flrt3 was highly expressed initially in the midbrain.
FLRT3 has an expression pattern during somite development
Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo.
Low FLRT3 expression is associated with lung graft dysfunction.
Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5.
This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development.
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
fibronectin leucine rich transmembrane protein 3
, Leucine-rich repeat transmembrane protein FLRT3
, Fibronectin-like domain-containing leucine-rich transmembrane protein 3
, leucine-rich repeat transmembrane protein FLRT3-like
, fibronectin-like domain-containing leucine-rich transmembrane protein 3
, leucine-rich repeat transmembrane protein FLRT3