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FBLN2 encodes an extracellular matrix protein, which belongs to the fibulin family.
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Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 (show ADAMTS5 Proteins) than it is for ADAMTS-4 (show ADAMTS4 Proteins). Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
levels of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment, suggesting a direct role for fibulin 2 in the re-attachment of the retina to the retinal pigment epithelium.
Study identified and validated a novel bona fide target of miR-1 (show FSD1 Proteins), Fibullin-2 (Fbln2), a secreted protein implicated in extracellular matrix remodeling.
Data provide evidence that FBLN2 short isoform (FBLN2S) has an important tumor-suppressive and anti-angiogenic role in nasopharyngeal carcinoma (NPC (show NPC1 Proteins)).
fibulin-1 (show FBLN1 Proteins) and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells
Our study indicates that Ang II (show AGT Proteins) cannot induce TGF-beta (show TGFB1 Proteins) activation without fibulin-2 and that fibulin-2 has an essential role in Ang II (show AGT Proteins)-induced TGF-beta (show TGFB1 Proteins) signaling and subsequent myocardial fibrosis. Fibulin-2 can be considered as a critical regulator of TGF-beta (show TGFB1 Proteins) that induces myocardial fibrosis.
These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 and other genes that promote matrix remodeling and invasion.
FBLN2 and VCAN (show Vcan Proteins) were both preferentially expressed in the mammary gland during times of epithelial expansion in TEB-enriched tissue and co-localised specifically in cap cell.
integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 induction, both in neonatal skin and in adult wounds
Data conclude that fibulin-2 is a driver of malignant progression in lung adenocarcinoma and plays an unexpected role in collagen cross-linking and tumor cell adherence to collagen.
Fibulin-2 is essential for angiotensin II-induced transforming growth factor-beta-mediated cardiac hypertrophy via enhanced TGF-beta (show TGFB1 Proteins) activation.
absence of fibulin-2 results in decreased up-regulation of TGF-beta (show TGFB1 Proteins) signaling after MI and protects against ventricular dysfunction.
Fibulin-2 and fibulin-5 (show FBLN5 Proteins) cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (show NID1 Proteins), fibulin-1 (show FBLN1 Proteins) and fibulin-2
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.