Fibulin 4 Proteins (FBLN4)

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. Additionally we are shipping Fibulin 4 Antibodies (109) and Fibulin 4 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat FBLN4 FBLN4 293677  
FBLN4 30008 O95967
FBLN4 58859 Q9WVJ9
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Top Fibulin 4 Proteins at antibodies-online.com

Showing 7 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$678.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$331.20
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$331.20
Details
Yeast Chinese Hamster His tag   1 mg Log in to see 60 to 71 Days
$3,162.50
Details

FBLN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,

More Proteins for Fibulin 4 (FBLN4) Interaction Partners

Human Fibulin 4 (FBLN4) interaction partners

  1. different mutations in the fibulin-4 gene result in different molecular defects affecting secretion rates, protein stability, LOX (show LOX Proteins)-induced cross-linking, or binding to other ECM (show MMRN1 Proteins) components and molecules of the TGF-beta (show TGFB1 Proteins) pathway.

  2. the expression of fibulin-4 was negatively correlated with the malignant phenotype of endometrial cancer cells. Fibulin-4 may have the ability to suppress endometrial cancer cell invasion and proliferation

  3. The results revealed that fibulin-4 expression was upregulated in osteosarcoma, and was positively correlated with low differentiation, lymph node metastasis, and poor prognosis. Fibulin-4 was also found to be over-expressed in highly invasive cell lines and in the highly invasive subclones

  4. link between Fibulin-4 and the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway that may contribute to our understanding of the molecular mechanisms of OA

  5. Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase (show LOX Proteins) which has a pivotal role in cross-linking of collagen and elastin (show ELN Proteins).

  6. Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features.

  7. pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice

  8. Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy.

  9. This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.

  10. The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls.

Mouse (Murine) Fibulin 4 (FBLN4) interaction partners

  1. These data clearly establish a functional link between Ltbp-4L and fibulin-4 as a crucial molecular requirement for survival and elastogenesis in mice.

  2. fibulin-4 seems to play a role in regulating tendon collagen fibrillogenesis, in addition to its essential function in elastogenesis.

  3. Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase (show LOX Proteins) which has a pivotal role in cross-linking of collagen and elastin (show ELN Proteins).

  4. These data provide new insights in the molecular interaction between Fibulin-4 and TGF-beta (show TGFB1 Proteins) pathway regulation in the pathogenesis of aortic aneurysms.

  5. Fibulin-4 serves as a potential scaffolding protein during collagen maturation in the extracellular space and loss of fibulin-4 disrupts collagen synthesis and maturation.

  6. fibulin-4 plays a role in regulating collagen fibril assembly and offer a preclinical platform for developing treatments for autosomal recessive cutis laxa 1B.

  7. MBP1 inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 to reduce Ab pathology and improve behavioral performance.

  8. pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice

  9. Smooth muscle cell (SMC (show DYM Proteins))-specific deletion of Fibulin-4 knockout ascending aorta and carotid artery showed mechanical changes in the axial direction.

  10. Compared to control SMCs, the modulus of Eln (show ELN Proteins)-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln (show ELN Proteins)-/- SMC (show DYM Proteins) modulus is rescued by soluble or alpha elastin (show ELN Proteins) treatment.

Fibulin 4 (FBLN4) Protein Profile

Protein Summary

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with Fibulin 4 Proteins (FBLN4)

  • EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)
  • EGF containing fibulin-like extracellular matrix protein 2b (efemp2b)
  • fibulin 4 (fbln4)
  • EGF containing fibulin like extracellular matrix protein 2 (EFEMP2)
  • epidermal growth factor-containing fibulin-like extracellular matrix protein 2 (Efemp2)
  • EGF containing fibulin like extracellular matrix protein 2 (Efemp2)
  • 0610011K11Rik protein
  • ARCL1B protein
  • CB257 protein
  • Fbln4 protein
  • fc56c09 protein
  • FIBL-4 protein
  • Fibulin-4 protein
  • H411 protein
  • id:ibd2923 protein
  • MBP1 protein
  • sb:cb257 protein
  • UPH1 protein
  • wu:fc56c09.x1 protein

Protein level used designations for Fibulin 4 Proteins (FBLN4)

fibulin 4 , EGF-containing fibulin-like extracellular matrix protein 2 , FIBL-4 , fibulin-4 , mutant p53 binding protein 1 , EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2) , mutant p53-binding protein 1 , Protein H411

GENE ID SPECIES
293677 Rattus norvegicus
572703 Danio rerio
100195030 Salmo salar
30008 Homo sapiens
58859 Mus musculus
100736553 Cricetulus griseus
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