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FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. Additionally we are shipping Flightless I Homolog (Drosophila) Antibodies (31) and Flightless I Homolog (Drosophila) Kits (5) and many more products for this protein.
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FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus.
Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1 (show TGFB1 Proteins)-mediated expression of COL1A2 (show COL1A2 Proteins) gene.
Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.
FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.
These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.
Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.
The mouse (Fli1 (show FLI1 Proteins)) and human Fli1 (show FLI1 Proteins) genes are similarly regulated by Ets (show ETS1 Proteins) factors in T cells.
Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.
These data suggest that Flightless-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins.
The gene that was most reproducibly up-regulated by EWS (show EWSR1 Proteins)/FLI was NR0B1 (show NR0B1 Proteins).
Flii genetic expression is enhances tissue regeneration, after claw amputation.
P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.
Genes downstream from Flii, including TGF-beta1 (show TGFB1 Proteins) and TGF-beta3 (show TGFB3 Proteins), showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression
FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.
FLII functions in PPARgamma (show PPARG Proteins) activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma (show PPARG Proteins)/RXRalpha (show RXRA Proteins) complex.
LRRFIP2 (show LRRFIP2 Proteins) inhibits NLRP3 (show NLRP3 Proteins) inflammasome activation by recruiting the caspase-1 (show CASP1 Proteins) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (show NLRP3 Proteins) inflammasome.
increasing the level of Flii in diabetic mouse wounds led to increased TLR4 (show TLR4 Proteins) and NF- kappa B (show NFKB1 Proteins) production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4 (show TLR4 Proteins)
Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.
These findings strongly demonstrate that the three single nucleotide polymorphisms of FLII gene could be utilized as molecular markers for future assisted selection in cattle breeding program.
Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.
fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.
FLI-1 controls germ line morphogenesis and rachis organization
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
protein flightless-1 homolog
, flightless I homolog (Drosophila)
, flightless-I homolog
, flightless I homolog