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FSTL1 encodes a protein with similarity to follistatin, an activin-binding protein. Additionally we are shipping FSTL1 Kits (65) and FSTL1 Proteins (31) and many more products for this protein.
Showing 10 out of 120 products:
Human Polyclonal FSTL1 Primary Antibody for ELISA, WB - ABIN249639
Tanaka, Ozaki, Osakada, Mori, Okubo, Nakao: Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. in International immunology 1998
Study found that FSTL1 was downregulated in non-small cell lung cancer (NSCLC) cells. FSTL1 overexpression suppressed tumor cell proliferation, altered cell cycle and induced apoptosis in addition to inhibiting cell survival, migration and invasion. Altogether, results revealed the critical tumor-suppression function of FSTL1 in NSCLC progression, suggesting it as an important factor in NSCLC progression.
Smad3 (show SMAD3 Antibodies) knockdown could restore the inhibition of cell proliferation induced by FSTL1 overexpression in MDAMB231FSTL1 cells, indicating that the antiproliferative effect of FSTL1 overexpression may be associated with Smad3 (show SMAD3 Antibodies) involved TGFbeta (show TGFB1 Antibodies) signaling pathway regulation. This study identified FSTL1 as an inhibitor of cell proliferation in MDAMB231 and 231BR cell lines
Dendritic cell-mediated immunity was activated by FSTL1.
Fstl1serves an important role in liver fibrosis and target deletion of Fstl1 attenuated HSCs activation through suppressing TGFbeta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.
Results showed that: 1- FSTL-1 expression is localized to the stromal compartment of the pancreas; 2- FSTL-1 expression is reduced in pancreatic cancer, and 3- FSTL-1 inhibited pancreatic cancer cell proliferation.
Data show that follistatin-like 1 (FSTL1) contributed to unfavorable post-surgical outcome of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients via inhibiting cell apoptosis.
results indicate that rs1259293 is associated with an increased risk and unfavorable postoperative prognosis of renal cell carcinoma (show MOK Antibodies), possibly by down-regulating FSTL1 expression in renal tissues.
Data provide evidence that FSTL1 modestly affects the proliferation of breast cancer cells and vascular endothelial cells. These findings improve the understanding of the functions of FSTL1 in breast cancer development and angiogenesis.
knockdown of FSTL1 inhibited ASM (show SMPD1 Antibodies) cell proliferation and migration induced by PDGF (show PDGFA Antibodies)-BB at least partially via inhibiting the activation of ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies). These results provide novel insight into the pathogenesis of airway remodeling in childhood asthma and FSTL1 may be a possible therapeutic strategy for the treatment of asthma.
Fstl1 inhibited Smad1 (show GARS Antibodies)/5/8 phosphorylation by blocking the association between bone morphogenetic protein 4 (show BMP4 Antibodies) and Bone Morphogenetic Protein Receptors, Type II via competitive binding to bone morphogenetic protein 4 (show BMP4 Antibodies).
this study shows that FSTL-1 modulates IL-17 (show IL17A Antibodies) signaling via IL-17RC (show IL17RC Antibodies) regulation in stromal cells
FSTL1 may exert its actions through the modulation of Akt (show AKT1 Antibodies) signaling.
FSTL1 is a secreted osteoclastogenic factor that plays a critical role in osteoclast formation via the NF-kappaB (show NFKB1 Antibodies) and MAPKs signaling pathways.
study indicates a pivotal role for Fstl1 in early stage of lung airway smooth muscle development
This study reveals that Fstl1 is essential for the acute repair of the infarcted myocardium and that stimulation of early fibroblast activation is a novel function of Fstl1.
Deletion of Fstl1 from the endocardial/endothelial lineage results in deformed mitral valves, which cause regurgitation, heart failure, and early cardiac death.
A critical role for the Smad3 (show SMAD3 Antibodies)-c-Jun (show JUN Antibodies) pathway in the regulation of Fstl1.
FSTL1 may induce epithelial mesenchymal transition and airway remodeling by activating autophagy.
tightly spatial interaction of FSTL1 and BMP4 (show BMP4 Antibodies) signaling plays an essential role in lung development
a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons, is reported.
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.
follistatin-like protein 1
, follistatin-related protein 1
, TGF-beta-inducible protein TSC-36
, follistatin-like 1
, Follistatin-related protein 1
, follistatin like 1 L homeolog