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FPGS encodes the folylpolyglutamate synthetase enzyme.
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Low expression level of FPGS is associated with neuroendocrine lung tumors.
Our results revealed a significant difference of overall survival between patients with AA genotype and GA + GG genotype (P<0.05). Our study demonstrated a correlation of the polymorphism of FPGS rs1544105 with MTX (show MTX1 Proteins) treatment efficacy, as well as with overall survival, suggesting it could be used as an effective approach in the prediction of MTX (show MTX1 Proteins) treatment efficacy
These results indicate that elevated expressions of the tumor-related genes FPGS/GGH (show GGH Proteins) and VEGF (show VEGFA Proteins) are correlated with malignancy of thymic carcinoma and B3 thymoma tumors.
529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX (show GGCX Proteins) rs12714145 and rs10654848, FPGS rs7856096, and STX1B (show STX1B Proteins) rs4889606.
data suggest that FPGS modulation affects global and promoter CpG DNA methylation (show HELLS Proteins) and expression of several genes involved in important biological pathways
the highest expression of GGH (show GGH Proteins) and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Proteins), FPGS, TOP1 (show TOP1 Proteins) and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP (show TYMP Proteins) expression was approximately equivalent in the right-sided colon and rectum
FPGS and ABCB1 (show ABCB1 Proteins) genetic variants can influence the outcome in RA patients receiving MTX (show MTX1 Proteins) monotherapy.
Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk.
study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma
antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12.
These results suggest that FPGS and GGH (show GGH Proteins) expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
, folylpolyglutamate synthase, mitochondrial
, folylpolyglutamate synthase
, folylpoly-gamma-glutamate synthetase
, tetrahydrofolate synthase
, tetrahydrofolylpolyglutamate synthase
, Folylpoly-gamma-glutamate synthetase
, Tetrahydrofolate synthase
, Tetrahydrofolylpolyglutamate synthase
, folylpoly-gammaglutamate synthetase