Forkhead Box E1 (Thyroid Transcription Factor 2) Proteins (FOXE1)

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. Additionally we are shipping FOXE1 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXE1 2304 O00358
FOXE1 110805 Q8R2I0
Rat FOXE1 FOXE1 192274  
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Top FOXE1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,041.50
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FOXE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) Interaction Partners

Human Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

  1. The meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.

  2. We confirmed the association of FOXE1 gene and cleft lip with or without cleft palate by a family based study. For the first time, rs1867277 was significantly associated with cleft lip with or without cleft palate

  3. Mutations of TTF2 is associated with risk of Papillary Thyroid Cancer in Chinese. Patients with Multiplendular goiter and no metastasis are more likely to suffer PTC. G/A mutation of TTF2 had a high correlation with PTC in the overall population.

  4. Report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor.

  5. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation

  6. The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to papillary thyroid carcinoma, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.

  7. FOXE1 interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk.

  8. In a Cuban population, differentiated thyroid cancer risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median.

  9. methylation-mediated silencing of FOXE1 expression may contribute to the progression of CRC.

  10. The rs965513 polymorphism is a risk factor for thyroid cancer.[meta-analysis]

  11. Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.

  12. We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis

  13. Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.

  14. FOXE1 polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression.

  15. In the analysis of all OFCs combined, SNPs near FOXE1 reached genome-wide significance

  16. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer

  17. FOXE1 was the only gene which was over-expressed in six out of eight lung cancer cell lines and human cancer tissue specimens and is an important regulator by targeting autophagy and Matrix Metalloproteinases pathways in lung cancer development.

  18. Taken together, this study showed that rs7043516 may be considered as a potentially susceptible marker of cleft lip only among Chinese Han populations.

  19. this study shows that FOXE1 polymorphism is strongly associated with non-syndromic cleft lip and palate in populations in northeast China

  20. High Levels of mRNA of both FOXE1 are associated with benign than in malignant thyroid lesions.

Mouse (Murine) Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

  1. These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.

  2. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.

  3. MSX1 and TGF-beta3 are direct targets of FOXE1.

  4. Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis.

  5. Foxe1 is required for hair follicle morphogenesis.

Xenopus laevis Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

  1. Xenopus FoxE1, a gene that is primarily expressed in the developing pituitary and thyroid

FOXE1 Protein Profile

Protein Summary

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.

Gene names and symbols associated with FOXE1

  • forkhead box E1 (FOXE1)
  • forkhead box E1 (Foxe1)
  • foxE protein (foxE)
  • forkhead box E1 L homeolog (foxe1.L)
  • forkhead box E1 (foxe1)
  • forkhead box E1 (foxE1)
  • Ci-FoxE protein
  • fkhl15 protein
  • foxE protein
  • foxE1 protein
  • foxe2 protein
  • FoxE5 protein
  • hfkh4 protein
  • hfkl5 protein
  • titf2 protein
  • ttf-2 protein
  • ttf2 protein

Protein level used designations for FOXE1

HNF-3/fork head-like protein 5 , forkhead box E2 , forkhead box protein E1 , forkhead box protein E2 , forkhead, drosophila, homolog-like 15 , forkhead-related protein FKHL15 , thyroid transcription factor 2 , TTF-2 , forkhead box E1 (thyroid transcription factor 2) , forkhead box E1 , forkhead box E protein

GENE ID SPECIES
2304 Homo sapiens
110805 Mus musculus
192274 Rattus norvegicus
445746 Ciona intestinalis
496399 Xenopus laevis
567676 Danio rerio
616734 Bos taurus
100038190 Xenopus (Silurana) tropicalis
100303469 Saccoglossus kowalevskii
100683977 Canis lupus familiaris
768789 Gallus gallus
100157892 Sus scrofa
101788559 Cavia porcellus
100348364 Oryctolagus cuniculus
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