Forkhead Box E1 (Thyroid Transcription Factor 2) Proteins (FOXE1)

Human Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

1. The meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.

2. We confirmed the association of FOXE1 gene and cleft lip with or without cleft palate by a family based study. For the first time, rs1867277 was significantly associated with cleft lip with or without cleft palate

3. Mutations of TTF2 is associated with risk of Papillary Thyroid Cancer in Chinese. Patients with Multiplendular goiter and no metastasis are more likely to suffer PTC. G/A mutation of TTF2 had a high correlation with PTC in the overall population.

4. Report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor.

5. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation

6. The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to papillary thyroid carcinoma, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.

7. FOXE1 interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk.

8. In a Cuban population, differentiated thyroid cancer risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median.

9. methylation-mediated silencing of FOXE1 expression may contribute to the progression of CRC.

10. The rs965513 polymorphism is a risk factor for thyroid cancer.[meta-analysis]

11. Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.

12. We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis

13. Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.

14. FOXE1 polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression.

15. In the analysis of all OFCs combined, SNPs near FOXE1 reached genome-wide significance

16. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer

17. FOXE1 was the only gene which was over-expressed in six out of eight lung cancer cell lines and human cancer tissue specimens and is an important regulator by targeting autophagy and Matrix Metalloproteinases pathways in lung cancer development.

18. Taken together, this study showed that rs7043516 may be considered as a potentially susceptible marker of cleft lip only among Chinese Han populations.

19. this study shows that FOXE1 polymorphism is strongly associated with non-syndromic cleft lip and palate in populations in northeast China

20. High Levels of mRNA of both FOXE1 are associated with benign than in malignant thyroid lesions.

Mouse (Murine) Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

1. These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.

2. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.

3. MSX1 and TGF-beta3 are direct targets of FOXE1.

4. Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis.

5. Foxe1 is required for hair follicle morphogenesis.

Xenopus laevis Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1) interaction partners

1. Xenopus FoxE1, a gene that is primarily expressed in the developing pituitary and thyroid