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This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. Additionally we are shipping FOXE1 Antibodies (56) and many more products for this protein.
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These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.
Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.
MSX1 (show MSX1 Proteins) and TGF-beta3 (show TGFB3 Proteins) are direct targets of FOXE1.
Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis.
Foxe1 is required for hair follicle morphogenesis.
methylation-mediated silencing of FOXE1 expression may contribute to the progression of CRC (show CALR Proteins).
Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis
Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.
FOXE1 polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression.
In the analysis of all OFCs combined, SNPs near FOXE1 reached genome-wide significance
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (show SERPINA5 Proteins) (rs2069974), FTO (show FTO Proteins) (rs8047395), EVPL (rs2071194), TICAM1 (show TICAM1 Proteins) (rs8120) and SCARB1 (show SCARB1 Proteins) (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5 (show SERPINA5 Proteins), FTO (show FTO Proteins), TICAM1 (show TICAM1 Proteins) and HSPA6 (show HSPA6 Proteins) and and follicular thyroid cancer
FOXE1 was the only gene which was over-expressed in six out of eight lung cancer cell lines and human cancer tissue specimens and is an important regulator by targeting autophagy and Matrix Metalloproteinases pathways in lung cancer development.
Taken together, this study showed that rs7043516 may be considered as a potentially susceptible marker of cleft lip only among Chinese Han populations.
this study shows that FOXE1 polymorphism is strongly associated with non-syndromic cleft lip and palate in populations in northeast China
Xenopus FoxE1, a gene that is primarily expressed in the developing pituitary and thyroid
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
forkhead box E1 (thyroid transcription factor 2)
, forkhead box E1
, forkhead box E protein
, thyroid transcription factor 2
, forkhead box protein E1
, HNF-3/fork head-like protein 5
, forkhead box E2
, forkhead box protein E2
, forkhead, drosophila, homolog-like 15
, forkhead-related protein FKHL15