Forkhead Box G1 Proteins (FOXG1)

This locus encodes a member of the forked-head transcription factor family. Additionally we are shipping FOXG1 Antibodies (107) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXG1 2290 P55316
FOXG1 15228 Q60987
Rat FOXG1 FOXG1 24370 Q00939
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Top FOXG1 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
Yeast Chicken His tag   1 mg 60 to 71 Days
Yeast Ceratotherium simum His tag   1 mg 60 to 71 Days
Yeast REACT_Capuchin Monkey His tag   1 mg 60 to 71 Days

FOXG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Forkhead Box G1 (FOXG1) Interaction Partners

Zebrafish Forkhead Box G1 (FOXG1) interaction partners

  1. Results suggest that foxg1b and foxg1c have undergone expression pattern divergence during evolution that has resulted in functional specialization.

  2. These findings identify a key direct target of Foxg1, and uncover a simple molecular mechanism by which Foxg1 integrates two opposing signaling centers.

Human Forkhead Box G1 (FOXG1) interaction partners

  1. FOXG1 is a gene identified as causative genes in atypical forms of Rett syndrome.

  2. miR-30a-5p showed a regulatory role on the expression of FOXG1 and further modulated the progression of cutaneous squamous cell carcinoma

  3. These results provide previously unavailable insight into the transcriptional programs underlying the tumour-promoting functions of FOXG1:TLE1 in glioblastoma.

  4. FOXG1 dose-dependently affect the cellular constitution of human brain, with 60% mildly affect GABAergic interneuron development while 30% thresholds the production of MGE derived neurons.

  5. findings suggest that FoxG1 functions as an onco-factor by promoting proliferation, as well as inhibiting differential responses in glioblastoma by downregulating FoxO/Smad signaling.

  6. FOXG1 expression is regulated by nitric oxide in the epidermal stem cells.FOXG1 induces transcriptional activity of the c-Myc gene promoter.

  7. Loss of regulatory elements within the refined critical region is the main cause of the FOXG1 syndrome in patients with structural rearrangements associated with long-range position effects.

  8. Patients with FOXG1 syndrome/congenital variant of Rett syndrome associated with pathogenic and likely pathogenic variants in the forkhead box G1 gene indicates substantial variability in overall severity of the phenotype.

  9. We report three cases of FOXG1-related syndrome...with three different underlying genotypes (14q12 deletion including the FOXG1 gene, FOXG1 intragenic mutation, 14q12 deletion including PRKD1 and a region regulating FOXG1 expression)

  10. A novel missense mutation was identified in FOXG1 on gene analysis (c. 569T>A, p. Ile190Asn). The patient showed not only the typical cerebral abnormalities of a congenital variant of Rett syndrome , but also a hypoplastic hippocampus. This novel mutation and cerebral findings may provide new insights into the pathophysiology of the congenital variant of Rett syndrome

  11. The genetic etiology of Rett syndrome (RTT) without MECP2, CDKL5, and FOXG1 mutations is heterogeneous, overlaps with other NDDs, and complicated by a high mutation burden. Dysregulation of chromatin structure and abnormal excitatory synaptic signaling may form two common pathological bases of RTT.

  12. FOXG1 and SOX2 operate in complementary but distinct roles to fuel unconstrained self-renewal in Glioblastoma multiforme stem cells via transcriptional control of core cell cycle and epigenetic regulators.

  13. phenotypes associated with FOXG1 mutations in Chinese Rett syndrome or Rett syndrome-like patients.

  14. describe the initial design and characterizations of novel covalent BH3-based agents that potently target Bfl-1

  15. findings demonstrate clear phenotype differences between FOXG1 and MECP2 disorders.

  16. Abnormal involuntary movements are a major feature of FOXG1 mutations. Our study delineates the spectrum of movement disorders and confirms an expanding clinical phenotype. Symptomatic treatment may be considered for severe or disabling cases, although further research regarding potential treatment strategies is necessary.

  17. Report demonstrates the functional consequences of Foxg1 haploinsufficiency in the visual system of Foxg1+/Cre mice and a visual impairment in a cohort of Rett individuals presenting genetic alteration on FOXG1

  18. Upregulated miR-200b in cervical cancer was proven to show positive regulation on cervical cancer development by directly targeting FoxG1.

  19. Rett syndrome with early epilepsy and the congenital variant are mainly due to variations in the CDKL5 and FOXG1 genes, respectively

  20. FOXG1 mutations are associated with familial recurrence in FOXG1-related disorders.

Mouse (Murine) Forkhead Box G1 (FOXG1) interaction partners

  1. Ecrg4 has a role in aging of neural stem cells in a Foxg1-dependent manner

  2. Study demonstrates that Foxg1 action in post-mitotic neurons is imperative to generate the cortical laminar structure in an inside-out fashion and to form the corpus callosum.

  3. Results indicate that knockout of Foxg1 induces an extra row of hair cells (HCs) via Notch signaling inhibition and induces subsequent apoptosis of these HCs by inhibiting the Wnt, IGF, and EGF signaling pathways. This study thus provides new evidence for the function and mechanism of FOXG1 in HC development and survival in mice.

  4. Foxg1 regulates the development of the epithalamus without the involvement of Shh and Fgfs.

  5. Prolyl-hydroxyproline promotes osteoblastic MC3T3-E1 cell differentiation and upregulation of osteogenic genes via Foxg1 expression.

  6. Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.

  7. Study reports a new role for Foxg1 as a critical upstream regulator of the development of cortical interneurons. Conditional inactivation of Foxg1 in the subpallium led to significant upregulation of transcription factors such as Dlx1/2, Mash1, and Prox1. Foxg1 plays a cell-autonomous role in regulating the development of cortical interneurons.

  8. Foxg1 was found to play a role in promoting the closure of optic fissure.

  9. Report demonstrates the functional consequences of Foxg1 haploinsufficiency in the visual system of Foxg1+/Cre mice and a visual impairment in a cohort of Rett individuals presenting genetic alteration on FOXG1

  10. The results presented here indicate that loss of Dlx5 causes a down-modulation of miR-9 and of miR-200-class, which results in the over-expression of the Foxg1 protein.

  11. Foxg1-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia

  12. findings suggest that different subcellular localizations of Foxg1 control the machinery that brings about cell differentiation, replication, and bioenergetics, possibly linking mitochondrial functions to embryonic development and pathological conditions

  13. EGFR mutations remodel the activated enhancer landscape of glioblastoma multiforme, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regulatory network in vitro and in vivo.

  14. This study demonistrated that Celsr3/Foxg1 mutation mice show the spinal motor network does not mature fully in the absence of corticofugal connections, and that some motor function is preserved despite congenital absence of the corticospinal tract.

  15. Foxg1 as a key coordinator of the early transcriptional network during the course of cortical development.

  16. target of Wnt/beta-catenin signalling, displayed significant upregulation of this pathway in Foxg1(-/-) nulls at embryonic days 12.5 and 14.5

  17. Targets of RBPJ/N1ICD in cortical neural stem cell at a genome-wide level, were identified

  18. the dynamic expression of FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex.

  19. We conclude that Foxg1 exerts control over telencephalic progenitor proliferation by cell autonomous mechanisms that include the regulation of Pax6

  20. The survival-promoting activity of FoxG1 in neurons is mediated by the PI-3 kinase-Akt signaling pathway, and FoxG1 is a downstream target of IGF-1-mediated signal transduction.

FOXG1 Protein Profile

Protein Summary

This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome.

Gene names and symbols associated with Forkhead Box G1 Proteins (FOXG1)

  • forkhead box G1a (foxg1a)
  • forkhead box G1 (foxg1)
  • brain factor 1 (bf-1)
  • forkfead transcription factor G1 (Foxg1)
  • forkhead box G1b (foxg1b)
  • forkhead box G1 (FOXG1)
  • forkhead box G1 L homeolog (foxg1.L)
  • forkhead box G1 (Foxg1)
  • 2900064B05Rik protein
  • bf-1 protein
  • Bf1 protein
  • BF1A protein
  • BF2 protein
  • BmFOXG1 protein
  • CBF-1 protein
  • FHKL3 protein
  • FKH2 protein
  • Fkhl1 protein
  • FKHL2 protein
  • FKHL3 protein
  • FKHL4 protein
  • FOXG1 protein
  • FOXG1A protein
  • FOXG1B protein
  • foxg1b-a protein
  • FOXG1C protein
  • HBF-1 protein
  • HBF-2 protein
  • HBF-3 protein
  • HBF-G2 protein
  • HBF2 protein
  • Hfh9 protein
  • Hfhbf1 protein
  • HFK1 protein
  • HFK2 protein
  • HFK3 protein
  • KHL2 protein
  • QIN protein
  • RATBF1A protein
  • XBF-1 protein
  • XBf1 protein
  • zgc:85969 protein
  • zgc:109850 protein

Protein level used designations for Forkhead Box G1 Proteins (FOXG1)

brain factor 1 , forkhead box G1 , forkhead box protein G1 , forkfead transcription factor G1 , brain factor 2 , forkhead-like 1 , forkhead-like 2 , forkhead-like 3 , forkhead-like 4 , oncogene QIN , BF-1 , FKH-4 , forkhead protein 4 , winged-helix transcription factor , xFKH4 , xbf1 , HNF-3/forkhead homolog, brain factor 1 , forkhead-related protein FKHL1 , BF1 , forkhead-like transcription factor BF-1 , transcription factor BF-1 , CEQ 3-1 , N-62-5 , brain factor-1 , proto-oncogene C-QIN

30274 Danio rerio
100144706 Xenopus (Silurana) tropicalis
100303459 Saccoglossus kowalevskii
100384886 Bombyx mori
405850 Danio rerio
100302450 Oryzias latipes
2290 Homo sapiens
373732 Xenopus laevis
15228 Mus musculus
24370 Rattus norvegicus
490636 Canis lupus familiaris
516947 Bos taurus
396110 Gallus gallus
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