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The functional integrity of lamin and nesprin-1 is thus required to modulate the FHOD1 activity and the inside-out mechanical coupling that tunes the cell internal stiffness to match that of its soft, physiological-like environment.
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results suggest that FHOD1 participates in key cellular processes that are dysregulated in malignancy
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FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes.
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Immunostaining of sections of hearts with both anti-FHOD1 antibodies confirmed the presence of FHOD1 in intercalated discs and double immunostaining demonstrated its colocalisation with cadherin, plakoglobin and shifted localization to connexin43.
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Report FODH1 expression in cardiomyocytes and increased expression in dilated cardiommyopathy.
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FHOD1 promotes formation of short actin filaments and transiently associates with transverse arcs providing tight temporal and spatial control of the formation and turnover of transverse arcs into mature ventral stress fibers during dynamic cell behavior.
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the diaphanous formin FHOD1 as an interaction partner of N2G
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FHOD1 participates in cytoskeletal changes in epithelial-mesenchymal transition.
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Cdh1 contributes to spatiotemporal organization of AurB activity, and organization of FHOD1 activity by AurB contributes to daughter cell spreading after mitosis.
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FHOD1 stabilizes actin filaments by protecting barbed ends from depolymerization with its dimeric FH2 domain, whereas the region N-terminal to the FH1 domain mediates F-actin bundling by simultaneously binding to the sides of adjacent F-actin filaments.
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SIRPalpha/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen.
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FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples.
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Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
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FHOD1 is a critical regulator of smooth muscle cell phenotype and is regulated by ROCK-dependent phosphorylation.
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FHOS mediates an interaction between GLUT4/IRAP (insulin-responsive aminopeptidase) -containing vesicles and the cytoskeleton and may participate in exocytosis and/or retention of this membrane compartment
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Fhos directly binds to F-actin via the N-terminal region, forms a homotypic complex via the FH2 domain to organize actin cytoskeleton
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FHOD1 has a role in cyclic GMP-dependent inhibition of vascular smooth muscle cell stress fiber formation and/or migration
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Oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities.
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Sustained cell elongation is a consequence of FHOD1-mediated actin-microtubule coordination.
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These novel data demonstrate that FHOD1-ERK MAP kinase interaction regulates key aspects of FHOD1 biology.
